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COVER: Lysophosphatidylcholine (lysoPC), a component of oxidized LDL and human arterial lesions, induces numerous changes in cells. At sublethal concentrations, lysoPC induced transient, reversible morphological changes in human dermal fibroblasts. Cells were treated with 6 mM lysoPC and monitored using time lapse photography. At 2 h (upper right) cells have undergone significant rounding compared to untreated, control cells (upper left). By 4 h (lower left) the cells have begun to recover; at 6 h (lower right) the cells have nearly fully resumed their normal morphology. (See Colles and Chisolm, p. 1188.)
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