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COVER: Interacting cycles of intracerebral de-esterification and re-esterification of plasma-brain exchange involving the PUFAs arachidonic acid and docosahexaenoic acid. The rapidly turning over intracerebral cycle (large arrows), promoted by activation of phospholipase A₂, is accompanied by metabolic losses at rates j_FA,catab (e.g., eicosanoids) and j_{acyl-CoA,catab} (-oxidation), and any backdiffusion to plasma J_out. In the absence of nutritional PUFA deprivation, these losses are entirely replaced by unesterified PUFA in plasma at a rate J_in (after taking synthesis J_synth into account). In awake rats, half-lives of PUFA recycling within brain phospholipids are hours, consistent with their participation in signal transduction, whereas their plasma-replacement half-lives are weeks. (See Rapoport, Chang, and Spector, p. 678.)
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