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COVER: Accumulation or depletion of intracellular glucosylceramide leads to changes in cholesterol distribution by filipin staining. Top left: control human fibroblasts. Top right: human fibroblasts treated with an inhibitor of glucosylceramide breakdown (CBE). Bottom, RAW mouse macrophages treated (left to right): control; CBE; an inhibitor of glucosylceramide synthesis (NB-DGJ); and exogenous glucosylceramide. Bar = 10 m. (See Sillence et al., p.1837.)
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