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COVER: Simplified cartoon of phospholipases A₂ at the synapse. Depolarization triggers release of glutamate, which in turn binds to the N-methyl-D-aspartate receptor and increases calcium influx into the postsynaptic neuron. Phospholipases A₂ release arachidonic acid (AA), docosahexaenoic acid (DHA), and lyso-platelet-activating factor (lyso-PAF), the precursor of platelet-activating factor. sPLA₂, secretory phospholipase A₂. (See Bazan, p. 2221.)
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