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COVER:
Plasma membrane lipid composition influences amyloid precursor protein (APP) metabolism. Cholesterol-poor regions of the plasma membrane favor the proteolytic pathway mediated by the "a disintegrin and metalloprotease" (ADAM) class of proteases, which cleave APP at the 
site and generate the neurotrophic APPs fragment.
In contrast, cholesterol- and sphingolipid-rich regions of the
plasma membrane, or lipid rafts, favor the proteolytic processing of APP at
the 
site by the -secretase/presinilin-1
(PS-1) protease complex and at the 
site by the beta-site APP-cleaving enzyme (BACE),
to generate the neurotoxic amyloid- peptide (A)
shown as a solid rectangle. (See Raffa
and Weisgraber,
p.1423.)
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Copyright © 2003 by the American Society for Biochemistry and Molecular Biology.
