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COVER: Canalicular membrane (CM) phosphatidylcholine (PC) synthesis, mdr2, and SR-BI may coordinately promote biliar y cholesterol excretion. CM-associated betaine homocysteine methyltransferase (BHMT) methylates homocysteine (H) to methionine (M). Methionine becomes a substrate for cytoplasmic methionine adenosyltransferase (MAT) that generates S-adenosylmethionine (SAM). SAM serves as a methyl group donor for CM-associated phosphatidylethanolamine N-methyltransferase (PEMT) that methylates PE to PC. CM-associated mdr2 promotes biliary excretion of PC and cholesterol. Finally, canalicular vesicles/micelles interact with CM-associated SR-BI to promote cholesterol excretion into bile. (See Sehayek et al., p.1605.)
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