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COVER: Current conception of nuclear structure. The majority of nuclear lipids are in the nuclear envelope (NE), consisting of inner and outer nuclear membranes (INM, ONM); ONM is continuous with smooth and rough endoplasmic reticulum (ER). Nucleoplasmic compartments contain low concentrations of lipids with important signaling functions. NE lumen, continuous with ER lumen, is storage site for Ca²⁺. Expansion shows a portion of INM containing Na⁺/Ca²⁺ exchanger in close association with GM1 ganglioside. Chro, chromatin; Heterochro, heterochromatin; H, histone; La, lamina; LA, lamin A; NPC, nuclear pore complex. (See Ledeen and Wu, p. 1.)
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