About the Cover
COVER:
Top: overall view of Mycobacterium tuberculosis 14α-demethylase (blue) in complex
with fluconazole (purple) and the distance separating fluconazole from phenylalanine 89 (red).
Middle: superposition of two bacterial cytochrome P450s: M. tuberculosis 14-demethylase (blue)
and P450 BM3 (yellow) in their B-C loop regions. The relative distances of their phenylalanines 89
and 87 (red) to the heme center (blue) are also shown.
Bottom: three-dimensional representation of lanosterol and the distances separating the C14-
and the two C4-methyl groups.
Distances are given in
, and figures were generated using SWISS-PDB VIEWER.
(See Bellamine, Lepesheva, and Waterman, p.
2000.)
[Table of Contents]
Copyright © 2004 by the American Society for Biochemistry and Molecular Biology.
