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Photomicrographs of cholesterol monohydrate crystal and gallstone formation observed in
wild-type (left panels) and Muc1-/- (right panels) mice during the
lithogenic diet feeding. Day 14 (top panels), agglomerated cholesterol monohydrate crystals
encircled by nonbirefringent amorphous mucin gel. Day 28 (middle panels), disintegratable
amorphous sandy stones surrounded by mucin gel, with individual cholesterol crystals
projected from the edges. Day 56 (bottom panels), gallstones display rounded contours
and black centers from light scattering/absorption. Most notably, the crystallization,
growth, and agglomeration of cholesterol monohydrate crystals, as well as the development
of gallstones, were significantly retarded in Muc1-/- mice compared
with wild-type mice. All magnifications are 400 except for the day 14 panels, which
are 800, by polarizing light microscopy.
(See Wang et al. p. 438.)
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Copyright © 2005 by the American Society for Biochemistry and Molecular Biology.
