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COVER: Growth of A549 cells is suppressed by eicosapentaenoic acid (EPA)-derived prostaglandin E₃ . Control cells (top left) appear green (calcein AM stained) while apoptotic cells affected by EPA appear blue (4',6-diamidino-2-phenylindole stained; top right panel). A selective cyclooxygenase 2 (COX-2) inhibitor, celecoxib, prevented growth inhibition by EPA (middle panels), whereas a COX-1 inhibitor failed to rescue EPA-treated cells (bottom panels). (See Yang et al., p. 1030.)
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