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COVER: Macrophage infiltration and inflammatory activation in white adipose tissue is implicated in the development of obesity complications, including insulin resistance. Dramatically elevated rates of adipocyte death in obese mice and humans and the selective localization of activated macrophages to these sites are demonstrated. At these sites, macrophages form syncytial crown-like structures and multinucleated giant cells that scavenge and sequester "free" adipocyte lipid. (See Cinti et al., p. 2347.)
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