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COVER: Uptake of oxidized LDL (OxLDL) and aggregated OxLDL by human monocyte-derived macrophages. Macrophages were loaded for 1 h with Alexa488-dextran (500μg/well, molecular weight 10,000, green) and incubated for 4 h with either Alexa546-labeled OxLDL (20μg/ml, top, red) or Alexa546-labeled aggregated OxLDL (AggOxLDL, 20μg/ml, bottom, red). Exposure to OxLDL (top) induces macrophage injury, but aggregation of OxLDL (bottom) promotes phagocytosis of the cytotoxic lipoproteins and allows macrophages to escape cell death. (See Asmis et al., p. 1124.)
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