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COVER: Lipid-enriched microdomains (red) of the plasma membrane of hepatocytes. Distinct membrane microdomain regions of the hepatocyte plasma membrane, enriched in cholesterol and sphingolipids, are thought to target and physically cluster functionally related "flux proteins" for water [aquaporins (AQP8, 9)], ions, solutes [chloride-bicarbonate anion exchanger isoform-2 (AE2) and multidrug resistance associated protein 2 (MRP2)] involved in canalicular bile secretion. Illustration by Stephen Boyd, Medical Illustrator. (See Tietz et al., p. 1426.)
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