About the Cover
COVER:
Artery wall depicted with an exaggerated subendothelial basement
membrane that contains endostatin (blue) and its
parent collagen XVIII proteoglycan. Endostatin binds other vascular wall
proteoglycans including biglycan (red) and interferes with retention
of LDL particles in the subendothelial matrix, a key event in atherosclerosis.
Increased biglycan and reduced endostatin levels in atheromas promote
further LDL retention. Depletion of endostatin, a normal component of
blood vessels, is both a consequence and a pathogenic mechanism of atherosclerosis.
Cover image provided by Kristin Gullage.
(See Zeng et al.,
p. 1849.)
[Table of Contents]
Copyright © 2007 by the American Society for Biochemistry and Molecular Biology.
