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COVER: Histologic section of the ovary from an npc1^−/−/mouse stained with hematoxylin and eosin. This shows atretic follicles surrounded by large numbers of vacuolated cells rather than by degenerating, apoptotic granulosa and thecal cells. Islands of swollen, vacuolated cells persist in the interstitium as well. (See Xie et al., p. 953.)
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