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COVER: Cytochrome c permeating a ceramide channel. The sphingolipid, ceramide, can self-assemble in the mitochondrial outer membrane to form channels capable of allowing proteins, such as cytochrome c (crystal structure shown in the center of the pore), to cross the membrane. Illustrated is the structure of a typical channel composed of 48 columns, each consisting of six ceramide monomers. The central aqueous pore is 10 nm in diameter. (See Stiban et al., p. 625.)
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