3 July 2009

Yu Zi Zheng and Leonard J. Foster

Contributions of quantitative proteomics to understanding membrane microdomains
J. Lipid Res. published July 3, 2009, doi:10.1194/jlr.R900018-JLR200 [Abstract] [Accepted Manuscript]  

Mariko Hotta, Rieko Nakata, Michiko Katsukawa, Kazuyuki Hori, Saori Takahashi, and Hiroyasu Inoue

Carvacrol, a component of thyme oil, activates PPAR and , and suppresses COX-2 expression
J. Lipid Res. published July 3, 2009, doi:10.1194/jlr.M900255-JLR200 [Abstract] [Accepted Manuscript]  

Nirupa R. Matthan, Nancy Resteghini, Michele Robertson, Ian Ford, James Shepherd, Chris Packard, Brendan M. Buckley, J. Wouter Jukema, Alice H. Lichtenstein, and Ernst J. Schaefer

Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: Insights from the PROSPER trial
J. Lipid Res. published July 3, 2009, doi:10.1194/jlr.M900032-JLR200 [Abstract] [Accepted Manuscript]  

2 July 2009

Fei Gao, Dale Kiesewetter, Lisa Chang, Kaizong Ma, Stanley I. Rapoport, and Miki Igarashi

Whole-body synthesis-secretion of docosahexaenoic acid from circulating Eicosapentaenoic acid in anesthetized rats
J. Lipid Res. published July 2, 2009, doi:10.1194/jlr.M900223-JLR200 [Abstract] [Accepted Manuscript]  

1 July 2009

Edward J. Flynn III, Chad M. Trent, and John F. Rawls

Ontogeny and nutritional control of adipogenesis in zebrafish (Danio rerio)
J. Lipid Res. published July 1, 2009, doi:10.1194/jlr.M800590-JLR200 [Abstract] [Accepted Manuscript]  

Naomi Sakashita, Catherine CY Chang, Xiaofeng Lei, Yukio Fujiwara, Motohiro Takeya, and Ta-Yuan Chang

Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity
J. Lipid Res. published July 1, 2009, doi:10.1194/jlr.M900288-JLR200 [Abstract] [Accepted Manuscript]  

Genevieve Dubuc, Michel Tremblay, Guillaume Pare, Helene Jacques, Josee Hamelin, Suzanne Benjannet, Lucie Boulet, Jacques Genest, Lise Bernier, Nabil G. Seidah, and Jean Davignon

A new method for measurement of total plasma PSCK9 - clinical applications
J. Lipid Res. published July 1, 2009, doi:10.1194/jlr.M900273-JLR200 [Abstract] [Accepted Manuscript]  

29 June 2009

Silvia Bijland, Sjoerd A .A. van den Berg, Peter J. Voshol, Anita M. van den Hoek, Hans M. G. Princen, Louis M. Havekes, Patrick C. N. Rensen, and Ko Willems van Dijk

CETP does not affect triglyceride production or clearance in APOE*3-leiden mice
J. Lipid Res. published June 29, 2009, doi:10.1194/jlr.M900186-JLR200 [Abstract] [Accepted Manuscript]  

27 June 2009

Akadiri Yessoufou, Aude Plé, Kabirou Moutairou, Aziz Hichami, and Naim Akhtar Khan

DHA reduces suppressive and migratory functions of Treg cells
J. Lipid Res. published June 27, 2009, doi:10.1194/jlr.M900101-JLR200 [Abstract] [Accepted Manuscript]  

26 June 2009

Sandrine Déchamps, Marjorie Maynadier, Sharon Wein, Laila Gannoun-Zaki, Eric Maréchal, and Henri J. Vial

Rodent and non-rodent malaria parasites differ in their phospholipid metabolic pathways
J. Lipid Res. published June 26, 2009, doi:10.1194/jlr.M900166-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

25 June 2009

Jingjing Liu, Nadezhda S. Sabeva, Saloni Bhatnagar, Xiangan Li, Aurora Pujol, and Gregory A. Graf

ABCD2 is abundant in adipose tissue and opposes the accumulation of dietary erucic acid (C22:1) in fat
J. Lipid Res. published June 25, 2009, doi:10.1194/jlr.M900237-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data] [Supplemental Data]  

24 June 2009

Markus Griesser, William E. Boeglin, Takashi Suzuki, and Claus Schneider

Convergence of the 5-LOX and COX-2 pathways. Heme-catalyzed cleavage of the 5S-HETE-derived di-endoperoxide into aldehyde fragments
J. Lipid Res. published June 24, 2009, doi:10.1194/jlr.M900181-JLR200 [Abstract] [Accepted Manuscript]  

22 June 2009

Eva Lattka, Stefanie Eggers, Gabriele Moeller, Katharina Heim, Martina Weber, Divya Mehta, Holger Prokisch, Thomas Illig, and Jerzy Adamski

A common FADS2 promoter polymorphism increases promoter activity and facilitates binding of transcription factor ELK1
J. Lipid Res. published June 22, 2009, doi:10.1194/jlr.M900289-JLR200 [Abstract] [Accepted Manuscript]  

Anna K.A. Aminoff, Helena Ledmyr, Petra Thulin, Kerstin Lundell, Leyla Nunez, Elisabeth Strandhagen, Charlotte Murphy, Ulf Lidberg, Jukka Westerbacka, Anders Franco-Cereceda, Jan Liska, Lars Bo Nielsen, Mats Gåfvels, Maria Nastase Mannila, Anders Hamsten, Hannele Yki-Järvinen, Dag Thelle, Per Eriksson, Jan Borén, and Ewa Ehrenborg

Allele-specific regulation of MTTP expression influences the risk of ischemic heart disease
J. Lipid Res. published June 22, 2009, doi:10.1194/jlr.M900195-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

Igor A. Butovich, Jadwiga Wojtowicz, and Mike Molai

Human tear film and meibum. I. Very long chain wax esters and (O-acyl)-omega-hydroxy fatty acids of meibum
J. Lipid Res. published June 22, 2009, doi:10.1194/jlr.M900252-JLR200 [Abstract] [Accepted Manuscript]  

21 June 2009

Doris T. Chan, Gursharan K. Dogra, Ashley B. Irish, Esther M. Ooi, P. Hugh R. Barrett, Dick C. Chan, and Gerald F. Watts

Chronic kidney disease delays VLDL apoB-100 particle catabolism: potential role of apo C-III
J. Lipid Res. published June 21, 2009, doi:10.1194/jlr.P900003-JLR200 [Abstract] [Accepted Manuscript]  

William K. Sonnenburg, Daiguan Yu, E-Chiang Lee, Wei Xiong, Gennady Gololobov, Billie Key, Jason Gay, Nat Wilganowski, Yi Hu, Sharon Zhao, Matthias Schneider, Zhi-Ming Ding, Brian P. Zambrowicz, Greg Landes, David R. Powell, and Urvi Desai

Glycosylphosphatidylinositol-anchored HDL-binding protein stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4
J. Lipid Res. published June 21, 2009, doi:10.1194/jlr.M900145-JLR200 [Abstract] [Accepted Manuscript]  

19 June 2009

Pilar Gomez-Cortes, Cynthia Tyburczy, J. Thomas Brenna, Manuela Juarez, and Miguel Angel De La Fuente

Characterization of cis-9 trans-11 trans-15 C18:3 in milk fat by gas chromatography and covalent adduct chemical ionization tandem mass spectrometry
J. Lipid Res. published June 19, 2009, doi:10.1194/jlr.M800662-JLR200 [Abstract] [Accepted Manuscript]  

17 June 2009

Fotini Apostolou, Irene F Gazi, Aggeliki Kostoula, Constadinos C. Tellis, Alexandros D. Tselepis, Moses Elisaf, and Evangelos N. Liberopoulos

Persistence of an atherogenic lipid profile after treatment of acute infection with Brucella
J. Lipid Res. published June 17, 2009, doi:10.1194/jlr.P900063-JLR200 [Abstract] [Accepted Manuscript]  

Brian M. Wiczer and David A. Bernlohr

A novel role for fatty acid transport protein 1 in the regulation of tricarboxylic acid cycle and mitochondrial function in 3T3-l1 adipocytes
J. Lipid Res. published June 17, 2009, doi:10.1194/jlr.M900218-JLR200 [Abstract] [Accepted Manuscript]  

15 June 2009

Junfei Jin, Thomas D. Mullen, Qi Hou, Jacek Bielawski, Alicja Bielawska, Xiaoming Zhang, Lina M. Obeid, Yusuf A. Hannun, and Yi-Te Hsu

AMPK inhibitor compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells
J. Lipid Res. published June 15, 2009, doi:10.1194/jlr.M900119-JLR200 [Abstract] [Accepted Manuscript]  

Ginny L. Weibel, Michelle R. Joshi, Cong Wei, Sandra R. Bates, Ian A. Blair, and George H. Rothblat

15(S)-lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism
J. Lipid Res. published June 15, 2009, doi:10.1194/jlr.M900081-JLR200 [Abstract] [Accepted Manuscript]  

10 June 2009

Wen-Jun Shen, Shailja Patel, Hideaki Miyoshi, Andrew S. Greenberg, and Fredric B. Kraemer

Functional interaction of hormone-sensitive lipase and perilipin in lipolysis
J. Lipid Res. published June 10, 2009, doi:10.1194/jlr.M900176-JLR200 [Abstract] [Accepted Manuscript]  

Daniël B. van Schalkwijk, Albert A. de Graaf, Ben van Ommen, Kees van Bochove, Patrick C.N. Rensen, Louis M. Havekes, Niek C.A. van de Pas, Huub C.J. Hoefsloot, Jan van der Greef, and Andreas P. Freidig

Improved cholesterol phenotype analysis by a model relating lipoprotein lifecycle processes to particle size
J. Lipid Res. published June 10, 2009, doi:10.1194/jlr.M800354-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

9 June 2009

Nicole O’Brien, S. Tarran Jones, David G. Williams, H. Brad Cunningham, Kelli Moreno, Barbara Visentin, Angela Gentile, John Vekich, William Shestowsky, Masao Hiraiwa, Rosalia Matteo, Amy Cavalli, Douglas Grotjahn, Maria Grant, Geneviève Hansen, Mary-Ann Campbell, and Roger Sabbadini

Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies
J. Lipid Res. published June 9, 2009, doi:10.1194/jlr.M900048-JLR200 [Abstract] [Accepted Manuscript]  

8 June 2009

Philippe Liere, Antoine Pianos, Bernard Eychenne, Annie Cambourg, Karl Bodin, William Griffiths, Michael Schumacher, Etienne-Emile Baulieu, and Jan Sjovall

Analysis of pregnenolone and dehydroepiandrosterone in rodent brain: Cholesterol autoxidation is the key
J. Lipid Res. published June 8, 2009, doi:10.1194/jlr.M900162-JLR200 [Abstract] [Accepted Manuscript]  

6 June 2009

Hye Won Kang, Scott Ribich, Brian W. Kim, Susan J. Hagen, Antonio C. Bianco, and David E. Cohen

Mice lacking phosphatidylcholine transfer protein/StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue
J. Lipid Res. published June 6, 2009, doi:10.1194/jlr.M900013-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data] [Supplemental Data]  

5 June 2009

Ulf Diczfalusy, Katarina E. Olofsson, Ann-Margreth Carlsson, Mei Gong, Douglas T. Golenbock, Olav Rooyackers, Urban Fläring, and Harry Björkbacka

Marked up-regulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
J. Lipid Res. published June 5, 2009, doi:10.1194/jlr.M900107-JLR200 [Abstract] [Accepted Manuscript]  

Michael R. Paillasse, Philippe de Medina, Guillaume Amouroux, Loubna Mhamdi, Marc Poirot, and Sandrine Silvente-Poirot

Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion
J. Lipid Res. published June 5, 2009, doi:10.1194/jlr.M800668-JLR200 [Abstract] [Accepted Manuscript]  

Shaikh Mizanoor Rahman, Ishtiaq Qadri, Rachel C. Janssen, and Jacob E. Friedman

Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis
J. Lipid Res. published June 5, 2009, doi:10.1194/jlr.M800633-JLR200 [Abstract] [Accepted Manuscript]  

4 June 2009

Paul A. Dawson, Tian Lan, and Anuradha Rao

Bile acid transporters
J. Lipid Res. published June 4, 2009, doi:10.1194/jlr.R900012-JLR200 [Abstract] [Accepted Manuscript]  

2 June 2009

Dmitry Namgaladze, Carla Jennewein, Stefan Preiss, Andreas von Knethen, and Bernhard Brüne

Attenuated suppression of the oxidative burst by cells dying in the presence of oxidized low density lipoprotein
J. Lipid Res. published June 2, 2009, doi:10.1194/jlr.M800615-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

27 May 2009

Jing Yan, Yuewen Gong, Yi-Min She, Guqi Wang, Michael S. Roberts, and Frank J. Burczynski

Molecular mechanism of recombinant liver fatty acid binding protein's antioxidant activity
J. Lipid Res. published May 27, 2009, doi:10.1194/jlr.M900177-JLR200 [Abstract] [Accepted Manuscript]  

Marjan Shafaati, Natalia Mast, Olof Beck, Rima Nayef, Gun Young Heo, Linda Björkhem-Bergman, Dieter Lutjohann, Ingemar Björkhem, and Irina A. Pikuleva

The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase (CYP46A1) in vitro and in vivo
J. Lipid Res. published May 27, 2009, doi:10.1194/jlr.M900174-JLR200 [Abstract] [Accepted Manuscript]  

Paola Elisa Cogo, Carlo Ori, Manuela Simonato, Giovanna Verlato, Ilena Isak, Aaron Hamvas, and Virgilio Paolo Carnielli

Metabolic precursors of surfactant disaturated-phosphatidylcholine in preterms with respiratory distress
J. Lipid Res. published May 27, 2009, doi:10.1194/jlr.M800514-JLR200 [Abstract] [Accepted Manuscript]  

26 May 2009

Fen Yin, Mark H Doolittle, and Miklós Péterfy

A quantitative assay measuring the function of lipase maturation factor 1 (Lmf1)
J. Lipid Res. published May 26, 2009, doi:10.1194/jlr.M900196-JLR200 [Abstract] [Accepted Manuscript]  

24 May 2009

Raffaele Marfella, Clara Di Filippo, Michele Portoghese, Michelangela Barbieri, Franca Ferraraccio, Mario Siniscalchi, Federico Cacciapuoti, Francesco Rossi, Michele D'Amico, and Giuseppe Paolisso

Myocardial lipid accumulation in patients with pressure-overloaded heart and metabolic syndrome
J. Lipid Res. published May 24, 2009, doi:10.1194/jlr.P900032-JLR200 [Abstract] [Accepted Manuscript]  

21 May 2009

Weijiang Dong, Simona Vuletic, and John J. Albers

Differential effects of simvastatin and pravastatin on expression of Alzheimer's disease-related genes in human astrocytes and neuronal cells
J. Lipid Res. published May 21, 2009, doi:10.1194/jlr.M900236-JLR200 [Abstract] [Accepted Manuscript]  

Jody C. Ullery-Ricewick, Brian E. Cox, Evelyn E. Griffin, and W. Gray Jerome

Triglyceride alters lysosomal cholesterol metabolism in cholesteryl ester-laden macrophage foam cells
J. Lipid Res. published May 21, 2009, doi:10.1194/jlr.M800659-JLR200 [Abstract] [Accepted Manuscript]  

Sana Basseri, Sarka Lhotak, Arya M. Sharma, and Richard C. Austin

The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response
J. Lipid Res. published May 21, 2009, doi:10.1194/jlr.M900216-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

20 May 2009

Silvia Sookoian, Gustavo O. Castaño, Adriana L. Burgueño, Tomas Fernández Gianotti, Maria Soledad Rosselli, and Carlos Jose Pirola

A nonsynonymous gene variant in adiponutrin gene is associated with nonalcoholic fatty liver disease severity
J. Lipid Res. published May 20, 2009, doi:10.1194/jlr.P900013-JLR200 [Abstract] [Accepted Manuscript]  

Reijiro Arakawa, Maki Tsujita, Noriyuki Iwamoto, Chisato Ito-Ohsumi, Rui Lu, Chen-Ai Wu, Kenji Shimizu, Tomoji Aotsuka, Hashime Kanazawa, Sumiko Abe-Dohmae, and Shinji Yokoyama

Pharmacological inhibition of ABCA1 degradation increases HDL biogenesis and exhibits antiatherogenesis
J. Lipid Res. published May 20, 2009, doi:10.1194/jlr.M900122-JLR200 [Abstract] [Accepted Manuscript] [Supplmental Data]  

Nicole Testerink, Michiel M.H. van der Sanden, Martin Houweling, J. Bernd Helms, and Arie B. Vaandrager

Depletion of phosphatidylcholine affects ER morphology and protein traffic at the Golgi complex
J. Lipid Res. published May 20, 2009, doi:10.1194/jlr.M800660-JLR200 [Abstract] [Accepted Manuscript]  

19 May 2009

Philipp Ternes, Jos F. H. M. Brouwers, Joep van den Dikkenberg, and Joost C. M. Holthuis

Sphingomyelin synthase SMS2 displays dual activity as ceramide phosphoethanolamine synthase
J. Lipid Res. published May 19, 2009, doi:10.1194/jlr.M900230-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

Berenice Ortiz, Lesley Wassef, Elena Shabrova, Lina Cordeddu, Sebastiano Banni, and Loredana Quadro

Hepatic retinol secretion and storage are altered by dietary conjugated linoleic acid (CLA): common and distinct actions of CLA c9,t11 and t10,c12 isomers
J. Lipid Res. published May 19, 2009, doi:10.1194/jlr.M900054-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

David V. Nguyen, Victor A. Drover, Martin Knopfel, Padmaja Dhanasekaran, Helmut Hauser, and Michael C. Phillips

Influence of class B scavenger receptors on cholesterol flux across the brush border membrane and intestinal absorption
J. Lipid Res. published May 19, 2009, doi:10.1194/jlr.M900036-JLR200 [Abstract] [Accepted Manuscript]  

14 May 2009

Bela F. Asztalos, Michael M. Swarbrick, Ernst J. Schaefer, Gerard E. Dallal, Katalin V. Horvath, Masumi Ai, Kimber L. Stanhope, Iselin Austrheim-Smith, Bruce M. Wolfe, Mohamed Ali, and Peter J. Havel

Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese women
J. Lipid Res. published May 14, 2009, doi:10.1194/jlr.P900015-JLR200 [Abstract] [Accepted Manuscript]  

Kenneth R. Feingold, Arthur Moser, Sophie M. Patsek, Judy K. Shigenaga, and Carl Grunfeld

Infection decreases fatty acid oxidation and nuclear hormone receptors in the diaphragm
J. Lipid Res. published May 14, 2009, doi:10.1194/jlr.M800655-JLR200 [Abstract] [Accepted Manuscript]  

13 May 2009

Carlos L.J. Vrins, Astrid E. Van der Velde, Karin Van den Oever, Johannes H.M. Levels, Stephane Huet, Ronald P.J. Oude Elferink, Folkert Kuipers, and Albert K. Groen

PPARd activation leads to increased trans intestinal cholesterol efflux
J. Lipid Res. published May 13, 2009, doi:10.1194/jlr.M800579-JLR200 [Abstract] [Accepted Manuscript]  

12 May 2009

Nirupa R. Matthan, Michael Pencina, Jane M. LaRocque, Paul F. Jacques, Ralph B. D'Agostino, Ernst J. Schaefer, and Alice H. Lichtenstein

Alterations in cholesterol absorption and synthesis characterize Framingham offspring study participants with coronary heart disease
J. Lipid Res. published May 12, 2009, doi:10.1194/jlr.P900039-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

James M. Cheverud, Gloria L. Fawcett, Joseph P. Jarvis, Elizabeth A. Norgard, Mihaela Pavlicev, L. Susan Pletscher, Kenneth S. Polonsky, Honggang Ye, Graeme I. Bell, and Clay F. Semenkovich

Calpain-10 is a component of the obesity-related quantitative trait locus, Adip1
J. Lipid Res. published May 12, 2009, doi:10.1194/jlr.M900128-JLR200 [Abstract] [Accepted Manuscript]  

Soonkyu Chung, Abraham K. Gebre, Jeongmin Seo, Gregory S. Shelness, and John S. Parks

A novel role for ABCA1-generated large pre-beta migrating nascent HDL in the regulationof hepatic VLDL triglyceride secretion
J. Lipid Res. published May 12, 2009, doi:10.1194/jlr.M900083-JLR200 [Abstract] [Accepted Manuscript]  

Zhiguang Su, Naoki Ishimori, Yaoyu Chen, Edward H. Leiter, Gary A. Churchill, Beverly Paigen, and Ioannis M. Stylianou

Four additional mouse crosses improve the lipid QTL landscape and identify Lipg as a QTL gene
J. Lipid Res. published May 12, 2009, doi:10.1194/jlr.M900076-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

Changcheng Zhou, Nakesha King, Kwan Y. Chen, and Jan L. Breslow

Activation of pregnane X receptor induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apolipoprotein E deficient mice
J. Lipid Res. published May 12, 2009, doi:10.1194/jlr.M800608-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

11 May 2009

Geoffrey D. Wool, Tomas Vaisar, Catherine A. Reardon, and Godfrey S. Getz

An apoA-I mimetic peptide containing a proline residue has greater in vivo HDL binding and anti-inflammatory ability than the 4F peptide
J. Lipid Res. published May 11, 2009, doi:10.1194/jlr.M900151-JLR200 [Abstract] [Accepted Manuscript]  

Chao Wang, Baoshan Xu, Bo Zhou, Cheng Zhang, Jie Yang, Hong Ouyang, Gang Ning, Meijia Zhang, Jianzhong Shen, and Guoliang Xia

Reducing CYP51 inhibits FSH-induced resumption of mouse oocyte meiosis in vitro
J. Lipid Res. published May 11, 2009, doi:10.1194/jlr.M800533-JLR200 [Abstract] [Accepted Manuscript]  

9 May 2009

David Sebastián, Maria Guitart, Celia García-Martínez, Caroline Mauvezin, Josep M. Orellana-Gavaldà, Dolors Serra, Anna M. Gómez-Foix, Fausto G. Hegardt, and Guillermina Asins

Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells
J. Lipid Res. published May 9, 2009, doi:10.1194/jlr.M800535-JLR200 [Abstract] [Accepted Manuscript]  

8 May 2009

Kristin E. Burnum, Dale S. Cornett, Satu M. Puolitaival, Stephen B. Milne, David S. Myers, Susanne Tranguch, H. Alex Brown, Sudhansu K. Dey, and Richard M. Caprioli

Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation
J. Lipid Res. published May 8, 2009, doi:10.1194/jlr.M900100-JLR200 [Abstract] [Accepted Manuscript]  

Gissette Reyes-Sofer, Steve Holleran, Wahida Karmally, Colleen Ngai, Niem-Tzu Chen, Margarita Torres, Rajasekhar Ramakrishan, William S. Blaner, Lars Berglund, Henry N. Ginsberg, and Catherine Tuck

Measures of postprandial lipoproteins are not associated with the presence of coronary artery disease in patients with type 2 diabetes mellitus
J. Lipid Res. published May 8, 2009, doi:10.1194/jlr.M900092-JLR200 [Abstract] [Accepted Manuscript]  

Toshiko Suzuki-Yamamoto, Kazunori Toida, Yukihiko Sugimoto, and Kazunori Ishimura

Colocalization of prostaglandin F₂ receptor FP and prostaglandin F synthase-I in the spinal cord
J. Lipid Res. published May 8, 2009, doi:10.1194/jlr.M800543-JLR200 [Abstract] [Accepted Manuscript]  

William C. Duane

Bile acids: developments new and very old
J. Lipid Res. published May 8, 2009, doi:10.1194/jlr.E900004-JLR200 [Abstract] [Accepted Manuscript]  

5 May 2009

Joana D. Amaral, Ricardo J.S. Viana, Rita M. Ramalho, Clifford J. Steer, and Cecília M.P. Rodrigues

Bile acids: regulation of apoptosis by ursodeoxycholic ccid
J. Lipid Res. published May 5, 2009, doi:10.1194/jlr.R900011-JLR200 [Abstract] [Accepted Manuscript]  

Yuki Sugiura, Yoshiyuki Konishi, Nobuhiro Zaima, Shigeki Kajihara, Hiroki Nakanishi, Ryo Taguchi, and Mitsutoshi Setou

Visualization of the cell-selective distribution of PUFA-containing phosphatidylcholines in mouse brain by imaging mass spectrometry
J. Lipid Res. published May 5, 2009, doi:10.1194/jlr.M900047-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

Jean-Paul Pais de Barros, Aurélia Boualam, Thomas Gautier, Laure Dumont, Bruno Vergès, David Masson, and Laurent Lagrost

Apolipoprotein ci is a physiological regulator of cholesteryl ester transfer protein activity in human plasma, but not in Rabbit plasma
J. Lipid Res. published May 5, 2009, doi:10.1194/jlr.M800588-JLR200 [Abstract] [Accepted Manuscript]  

3 May 2009

Robert J. Brown, Andrew C. Edmondson, Nathalie Griffon, Theophelus B. Hill, Ilia V. Fuki, Karen O. Badellino, Mingyao Li, Megan L. Wolfe, Muredach P. Reilly, and Daniel J. Rader

A naturally occurring variant of endothelial lipase associated with elevated HDL exhibits impaired synthesis
J. Lipid Res. published May 3, 2009, doi:10.1194/jlr.P900020-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

29 April 2009

Akira Honda, Kouwa Yamashita, Tadashi Ikegami, Takashi Hara, Teruo MIyazaki, Takeshi Hirayama, Mitsuteru Numazawa, and Yasushi Matsuzaki

Highly-sensitive quantification of serum malonate, a possible marker for de novo lipogenesis, by LC-ESI-MS/MS
J. Lipid Res. published April 29, 2009, doi:10.1194/jlr.D800054-JLR200 [Abstract] [Accepted Manuscript]  

28 April 2009

Yvonne Lange, Theodore L. Steck, Jin Ye, M. Hunter Lanier, Vasumathi Molugu, and Daniel S. Ory

Regulation of fibroblast mitochondrial 27-hydroxycholesterol production by active plasma membrane cholesterol
J. Lipid Res. published April 28, 2009, doi:10.1194/jlr.M900116-JLR200 [Abstract] [Accepted Manuscript]  

Ping Zhou, Vandana Chandan, Xin Liu, Kenneth Chan, Eleonora Altman, and Jianjun Li

Microwave-assisted sample preparation for rapid and sensitive analysis of Helicobacter pylori lipid A applicable to a single colony
J. Lipid Res. published April 28, 2009, doi:10.1194/jlr.D900013-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

25 April 2009

Aurelia Ouvrier, Remi Cadet, Patrick Vernet, Brigitte Lallier, Jean-Michel Chardigny, Jean-Marc Lobaccaro, Joel R. Drevet, and Fabrice Saez

LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell specific manner
J. Lipid Res. published April 25, 2009, doi:10.1194/jlr.M800657-JLR200 [Abstract] [Accepted Manuscript]  

24 April 2009

Anna Cabre, Iolanda Lazaro, Montserrat Cofan, Estibaliz Jarauta, Nuria Plana, Angel L. Garcia-Otin, Juan F. Ascaso, Raimon Ferre, Fernando Civeira, Emilio Ros, and Lluis Masana

FABP4 plasma levels are increased in familial combined hyperlipidemia
J. Lipid Res. published April 24, 2009, doi:10.1194/jlr.M900066-JLR200 [Abstract] [Accepted Manuscript]  

22 April 2009

Xiaoyue Pan and M. Mahmood Hussain

Clock is important for food and circadian regulation of macronutrient absorption in mice
J. Lipid Res. published April 22, 2009, doi:10.1194/jlr.M900085-JLR200 [Abstract] [Accepted Manuscript]  

21 April 2009

Michael D. Jensen, Jiri Bajnarek, Sang Yeoup Lee, Soren Nielsen, and Christina Koutsari

Relationship between postabsorptive respiratory exchange ratio and plasma free fatty acid concentrations
J. Lipid Res. published April 21, 2009, doi:10.1194/jlr.M900021-JLR200 [Abstract] [Accepted Manuscript]  

Takeshi Harayama, Hideo Shindou, and Takao Shimizu

Biosynthesis of phosphatidylcholine by human lysophosphatidylcholine acyltransferase 1
J. Lipid Res. published April 21, 2009, doi:10.1194/jlr.M800500-JLR200 [Abstract] [Accepted Manuscript]  

Wei Qiu, Qiaozhu Su, Angela C Rutledge, Jing Zhang, and Khosrow Adeli

Glucosamine-induced ER stress attenuates apolipoprotein B100 synthesis via PERK signaling
J. Lipid Res. published April 21, 2009, doi:10.1194/jlr.M800343-JLR200 [Abstract] [Accepted Manuscript]  

20 April 2009

Thomas Sudhop, Michael Reber, Diane Tribble, Aditi Sapre, William Taggart, Patrice Gibbons, Thomas Musliner, Klaus von Bergmann, and Dieter Lütjohann

Changes in cholesterol absorption and cholesterol synthesis caused by ezetimibe and/or simvastatin in men
J. Lipid Res. published April 20, 2009, doi:10.1194/jlr.P900004-JLR200 [Abstract] [Accepted Manuscript]  

16 April 2009

Sonya J. Elder, Alice H. Lichtenstein, Anastassios G. Pittas, Susan B. Roberts, Paul J. Fuss, Andrew S. Greenberg, Megan A. McCrory, Thomas J. Bouchard . Jr, Edward Saltzman, and Michael C. Neale

Genetic and environmental influences on factors associated with cardiovascular disease and the metabolic syndrome
J. Lipid Res. published April 16, 2009, doi:10.1194/jlr.P900033-JLR200 [Abstract] [Accepted Manuscript]  

Guanghu Wang, Kannan Krishnamurthy, and Erhard Bieberich

Regulation of primary cilia formation by ceramide
J. Lipid Res. published April 16, 2009, doi:10.1194/jlr.M900097-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

Shengjie Li, Xi Chen, Hongjie Zhang, Xiangying Liang, Yang Xiang, Chaohui Yu, Ke Zen, Youming Li, and Chen-Yu Zhang

Differential expression of MicroRNAs in mouse liver under aberrant energy metabolic status
J. Lipid Res. published April 16, 2009, doi:10.1194/jlr.M800509-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

15 April 2009

Wei Hu, Jacek Bielawski, Fahumiya Samad, Alfred H. Merrill . Jr, and L. Ashley Cowart

Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity
J. Lipid Res. published April 15, 2009, doi:10.1194/jlr.M800635-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

Shin-ya Morita, Kazumitsu Ueda, and Shuji Kitagawa

Enzymatic measurement of phosphatidic acid in cultured cells
J. Lipid Res. published April 15, 2009, doi:10.1194/jlr.D900014-JLR200 [Abstract] [Accepted Manuscript]  

11 April 2009

So-Ra Oh, Ok-Joo Sul, Youn-Young Kim, Hye-Jin Kim, Rina Yu, Jae-Hee Suh, and Hye-Seon Choi

Saturated fatty acids enhance osteoclast survival
J. Lipid Res. published April 11, 2009, doi:10.1194/jlr.M800626-JLR200 [Abstract] [Accepted Manuscript]  

9 April 2009

Kasey C. Vickers, Colin T. Maguire, Robert Wolfert, Alan R. Burns, Michael Reardon, Richard Geis, Paul Holvoet, and Joel D. Morrisett

Relationship of lipoprotein-associated phospholipase A₂ and oxidized low-density lipoprotein in carotid atherosclerosis
J. Lipid Res. published April 9, 2009, doi:10.1194/jlr.M800342-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

David F. Schaeffer, Maziar Riazy, Kuljit S. Parhar, Johnny H. Chen, Vincent Duronio, Tatsuya Sawamura, and Urs P. Steinbrecher

LOX-1 augments oxLDL uptake by lysophosphatidylcholine-stimulated murine macrophages but is not required for oxLDL clearance from plasma
J. Lipid Res. published April 9, 2009, doi:10.1194/jlr.M900167-JLR200 [Abstract] [Accepted Manuscript]  

8 April 2009

Sacha Ferdinandusse, Simone Denis, Phyllis L. Faust, and Ronald J.A. Wanders

Bile acids: Role of peroxisomes
J. Lipid Res. published April 8, 2009, doi:10.1194/jlr.R900009-JLR200 [Abstract] [Accepted Manuscript]  

7 April 2009

Chad K. Stroud, Takayuki Y. Nara, Manuel Roqueta-Rivera, Emily C. Radlowski, Peter Lawrence, Ying Zhang, Byung H. Cho, Mariangela Segre, Rex A. Hess, J. Thomas Brenna, Wanda M. Haschek, and Manabu T. Nakamura

Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulceration
J. Lipid Res. published April 7, 2009, doi:10.1194/jlr.M900039-JLR200 [Abstract] [Accepted Manuscript]  

Shilpa Jain, Xiaoling Zhang, Preeti J. Khandelwal, Aleister J. Saunders, Brian S. Cummings, and Peter Oelkers

Characterization of human lysophospholipid acyltransferase 3 (LPCAT3)
J. Lipid Res. published April 7, 2009, doi:10.1194/jlr.M800398-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

6 April 2009

Yoshinori Masukawa, Hirofumi Narita, Hirayuki Sato, Ayano Naoe, Naoki Kondo, Yoshiya Sugai, Tsuyoshi Oba, Rika Homma, Junko Ishikawa, Yutaka Takagi, and Takashi Kitahara

Comprehensive quantification of ceramide species in human stratum corneum
J. Lipid Res. published April 6, 2009, doi:10.1194/jlr.D800055-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

3 April 2009

John Y.L. Chiang

Bile acids: regulation of synthesis
J. Lipid Res. published April 3, 2009, doi:10.1194/jlr.R900010-JLR200 [Abstract] [Accepted Manuscript]  

Phillip B. Hylemon, Huiping Zhou, William M. Pandak, Shunlin Ren, Gregorio Gil, and Paul Dent

Bile acids as regulatory molecules
J. Lipid Res. published April 3, 2009, doi:10.1194/jlr.R900007-JLR200 [Abstract] [Accepted Manuscript]  

Keri L. Monda, Christie M. Ballantyne, and Kari E. North

Longitudinal impact of physical activity on lipid profiles in middle-aged adults: the atherosclerosis risk in communities (ARIC) study
J. Lipid Res. published April 3, 2009, doi:10.1194/jlr.P900029-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

30 March 2009

Eric D. Bischoff, Chris L. Daige, Mary Petrowski, Harry Dedman, Jennifer Pattison, Joseph Juliano, Andrew C. Li, and Ira G. Schulman

Non-Redundant Roles for LXR and LXR in Atherosclerosis Susceptibility in Low Density Receptor Knockout Mice
J. Lipid Res. published March 30, 2009, doi:10.1194/jlr.M900096-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

26 March 2009

Jiang Wang, Bei-Bei Chu, Liang Ge, Bo-Liang Li, Yan Yan, and Bao-Liang Song

Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption
J. Lipid Res. published March 26, 2009, doi:10.1194/jlr.M800669-JLR200 [Abstract] [Accepted Manuscript]  

25 March 2009

Akira Abe and James A. Shayman

The role of negatively charged lipids in lysosomal phospholipase A2 function
J. Lipid Res. published March 25, 2009, doi:10.1194/jlr.M900008-JLR200 [Abstract] [Accepted Manuscript]  

24 March 2009

Elaine M. Quinet, Michael D. Basso, Anita R. Halpern, David W. Yates, Robert J. Sheffan, Valerie Clerin, Christine Resmini, James C. Keith, Thomas J. Berrodin, Irene Feingold, Wenyan Zhong, Helen B. Hartman, Mark J. Evans, Stephen J. Gardell, Elizabeth DiBlasio-Smith, William M. Mounts, Edward R. LaVallie, Jay Wrobel, Ponnal Nambi, and George P. Vlasuk

LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse
J. Lipid Res. published March 24, 2009, doi:10.1194/jlr.M900037-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

21 March 2009

Jessica M. Sapiro, Mara T. Mashek, Andrew S. Greenberg, and Douglas G. Mashek

Hepatic triacylglycerol hydrolysis regulates PPAR- activity
J. Lipid Res. published March 21, 2009, doi:10.1194/jlr.M800614-JLR200 [Abstract] [Accepted Manuscript]  

17 March 2009

Michael K. Pickens, Jim S. Yan, Raymond K. Ng, Hisanobu Ogata, James P. Grenert, Carine Beysen, Scott M. Turner, and Jacquelyn J. Maher

Dietary sucrose is essential to the development of liver injury in the MCD model of steatohepatitis
J. Lipid Res. published March 17, 2009, doi:10.1194/jlr.M900022-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

16 March 2009

Heather A. Hostetler, Avery L. McIntosh, Barbara P. Atshaves, Stephen M. Storey, H. Ross Payne, Ann B. Kier, and Friedhelm Schroeder

Liver type fatty acid binding protein (L-FABP) directly interacts with peroxisome proliferator-activated receptor- in cultured primary hepatocytes
J. Lipid Res. published March 16, 2009, doi:10.1194/jlr.M900058-JLR200 [Abstract] [Accepted Manuscript]  

12 March 2009

Zhengping Ma, Ching-Hsuen Chu, and Dong Cheng

A novel direct homogeneous assay for ATP citrate lyase
J. Lipid Res. published March 12, 2009, doi:10.1194/jlr.D900008-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

11 March 2009

Laura K. Potter, Dennis L. Sprecher, Max C. Walker, and Frank L. Tobin

Mechanism of inhibition defines CETP activity: A mathematical model for CETP in vitro
J. Lipid Res. published March 11, 2009, doi:10.1194/jlr.M900015-JLR200 [Abstract] [Accepted Manuscript]  

5 March 2009

Christopher L. Rector and Robert C. Murphy

Determination of Leukotriene A4 stabilization by S100A8/A9 proteins Using Mass spectrometry
J. Lipid Res. published March 5, 2009, doi:10.1194/jlr.M900017-JLR200 [Abstract] [Accepted Manuscript]  

28 February 2009

Harmen Wiersma, Alberto Gatti, Niels Nijstad, Folkert Kuipers, and Uwe J. F. Tietge

Hepatic SR-BI but not endothelial lipase (EL) expression determines biliary cholesterol secretion in mice
J. Lipid Res. published February 28, 2009, doi:10.1194/jlr.M800434-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

18 February 2009

Mohamad Navab, Piotr Ruchala, Alan J. Waring, Robert I. Lehrer, Susan Hama, Greg Hough, Mayakonda N. Palgunachari, G. M. Anantharamaiah, and Alan M. Fogelman

A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids
J. Lipid Res. published February 18, 2009, doi:10.1194/jlr.M800539-JLR200 [Abstract] [Accepted Manuscript]  

13 January 2009

Sita D. Gupta, Kenneth Gable, Gongshe Han, Anna Borovitskaya, Luke Selby, Teresa M. Dunn, and Jeffrey M. Harmon

TSC10p and FVT1: Topologically distinct short chain reductases required for long-chain base synthesis in yeast and mammals
J. Lipid Res. published January 13, 2009, doi:10.1194/jlr.M800580-JLR200 [Abstract] [Accepted Manuscript]  

19 December 2008

Paul S. Hauser, Vincent Raussens, Taichi Yamamoto, Gezman E. Abdullahi, Paul M. M. Weers, Brian D. Sykes, and Robert O. Ryan

Semisynthesis and segmental isotope labeling of apoE3 N-terminal domain using expressed protein ligation
J. Lipid Res. published December 19, 2008, doi:10.1194/jlr.M800554-JLR200 [Abstract] [Accepted Manuscript]  

18 December 2008

Teresa A. Garrett, Christian R. H. Raetz, Travis Richardson, Reza Kordestani, Jennifer D. Son, and Rebecca L. Rose

Identification of phosphatidylserylglutamtate: A novel minor lipid in Escherichia coli
J. Lipid Res. published December 18, 2008, doi:10.1194/jlr.M800549-JLR200 [Abstract] [Accepted Manuscript]  

16 December 2008

Rita Romani, Gianna Evelina De Medio, Simona di Tullio, Rosa Lapalombella, Irene Pirisinu, Vittoria Margonato, Arsenio Veicsteinas, Marina Marini, and Gabriella Rosi

Modulation of paraoxonase 1 and 3 expression after moderate exercise training in the rat
J. Lipid Res. published December 16, 2008, doi:10.1194/jlr.M800493-JLR200 [Abstract] [Accepted Manuscript]  

15 December 2008

Dayanjan S. Wijesinghe, Preeti Subramanian, Nadia F. Lamour, Luciana B. Gentile, Maria H. Granado, Zdzislaw Szulc, Alicja Bielawska, Antonio Gomez-Munoz, and Charles E. Chalfant

The chain length specificity for the activation of group IV cytosolic phospholipase A₂ by ceramide-1-phosphate. Use of the dodecane delivery system for determining lipid-specific effects
J. Lipid Res. published December 15, 2008, doi:10.1194/jlr.M800367-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

13 December 2008

Radhia Mahfoud, Adam Manis, and Clifford A. Lingwood

Fatty acid-dependent globotriaosyl ceramide receptor function in detergent resistant model membranes
J. Lipid Res. published December 13, 2008, doi:10.1194/jlr.M800385-JLR200 [Abstract] [Accepted Manuscript]  

12 December 2008

Soazig Le Lay, Qiong Li, Nicholas Proschogo, Macarena Rodriguez, Krishanthi Gunaratnam, Siân Cartland, Carles Rentero, Wendy Jessup, Todd Mitchell, and Katharina Gaus

Caveolin-1-dependent and -independent membrane domains
J. Lipid Res. published December 12, 2008, doi:10.1194/jlr.M800601-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

6 December 2008

Yi Luo, Laurie Warren, Donghui Xia, Heather Jensen, Thomas Sand, Stephen Petras, Wenning Qin, Kenneth S. Miller, and Julie Hawkins

Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice
J. Lipid Res. published December 6, 2008, doi:10.1194/jlr.M800542-JLR200 [Abstract] [Accepted Manuscript]  

3 December 2008

Bo Zhang, Akira Matsunaga, David L. Rainwater, Shin-ichiro Miura, Keita Noda, Hiroaki Nishikawa, Yoshinari Uehara, Kazuyuki Shirai, Masahiro Ogawa, and Keijiro Saku

Effects of ROSuvastatin on electronegative LDL as characterized by CapillARY isotachophoresis: The ROSARY study
J. Lipid Res. published December 3, 2008, doi:10.1194/jlr.M800523-JLR200 [Abstract] [Accepted Manuscript]  

25 November 2008

Rebecca L. Shaner, Jeremy C. Allegood, Hyejung Park, Elaine Wang, Samuel Kelly, Christopher A. Haynes, M. Cameron Sullards, and Alfred H. Merrill . Jr

Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers
J. Lipid Res. published November 25, 2008, doi:10.1194/jlr.D800051-JLR200 [Abstract] [Accepted Manuscript] [Supplemental Data]  

17 November 2008

Andrei Maiseyeu, Georgeta Mihai, Thomas Kampfrath, Orlando P Simonetti, Chandan K Sen, Sashwati Roy, Sanjay Rajagopalan, and Sampath Parthasarathy

Gadolinium containing phosphatidylserine liposomes for molecular imaging of atherosclerosis
J. Lipid Res. published November 17, 2008, doi:10.1194/jlr.M800405-JLR200 [Abstract] [Accepted Manuscript]  

11 November 2008

Kate S. Collison, Zakia Maqbool, Soad M. Saleh, Angela Inglis, Nadine J. Makhoul, Razan Bakheet, Mohammed Al-Johi, Rana Al-Rabiah, Marya Z. Zaidi, and Futwan A. Al-Mohanna

Effect of dietary monosodium glutamate on trans fat-induced nonalcoholic fatty liver disease
J. Lipid Res. published November 11, 2008, doi:10.1194/jlr.M800418-JLR200 [Abstract] [Accepted Manuscript]  

10 November 2008

Harjot K. Saini-Chohan, Michael G. Holmes, Adam J. Chicco, William A. Taylor, Russell L. Moore, Sylvia A. McCune, Diane L. Hickson-Bick, Grant M. Hatch, and Genevieve C. Sparagna

Cardiolipin biosynthesis and remodeling enzymes are altered during the development of heart failure
J. Lipid Res. published November 10, 2008, doi:10.1194/jlr.M800561-JLR200 [Abstract] [Accepted Manuscript]  

31 October 2008

Frank ter Veld, Sonja Primassin, Lars Hoffmann, Ertan Mayatepek, and Ute Spiekerkoetter

Corresponding increase in long-chain acyl-CoA and acylcarnitine after exercise in muscle from very long-chain acyl-CoA dehydrogenase-deficient mice
J. Lipid Res. published October 31, 2008, doi:10.1194/jlr.M800221-JLR200 [Abstract] [Accepted Manuscript]  

20 February 2008

Purna Mukherjee, Anthony C. Faber, Laura M. Shelton, Rena C. Baek, Thomas C. Chiles, and Thomas N. Seyfried

Ganglioside GM3 suppresses the pro-angiogenic effects of vascular endothelial growth factor and ganglioside GD1A
J. Lipid Res. published February 20, 2008, doi:10.1194/jlr.M800002-JLR200 [Abstract] [Accepted Manuscript]  

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