BILE ACID METABOLISM AND PHYSIOLOGY
KEY MECHANISMS OF APOPTOSIS
BIOCHEMICAL PATHWAYS OF APOPTOSIS
Death receptor pathway
Cell cycle and apoptosis
BILE ACID INDUCTION OF APOPTOSIS
- Qiao L.
- Studer E.
- Leach K.
- McKinstry R.
- Gupta S.
- Decker R.
- Kukreja R.
- Valerie K.
- Nagarkatti P.
- El Deiry W.
- et al.
BILE ACID INHIBITION OF APOPTOSIS
Cell survival signaling
- Qiao L.
- Studer E.
- Leach K.
- McKinstry R.
- Gupta S.
- Decker R.
- Kukreja R.
- Valerie K.
- Nagarkatti P.
- El Deiry W.
- et al.
- Qiao L.
- Han S.I.
- Fang Y.
- Park J.S.
- Gupta S.
- Gilfor D.
- Amorino G.
- Valerie K.
- Sealy L.
- Engelhardt J.F.
- et al.
- Gupta S.
- Natarajan R.
- Payne S.G.
- Studer E.J.
- Spiegel S.
- Dent P.
- Hylemon P.B.
UDCA modulation of apoptosis
- Wali R.K.
- Khare S.
- Tretiakova M.
- Cohen G.
- Nguyen L.
- Hart J.
- Wang J.
- Wen M.
- Ramaswamy A.
- Joseph L.
- et al.
Crosstalk between bile acids and NSRs
- Tanaka H.
- Makino Y.
- Miura T.
- Hirano F.
- Okamoto K.
- Komura K.
- Sato Y.
- Makino I.
BILE ACIDS AS TREATMENT OF EXPERIMENTAL NEURODEGENERATIVE DISORDERS
Inhibition of neuronal apoptosis by bile acids
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- Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells.Hepatology. 2002; 36: 315-325
- Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes. Role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation.J. Biol. Chem. 2004; 279: 5821-5828
- The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade.J. Biol. Chem. 2000; 275: 20210-20216
- Differential modulation of cellular death and survival pathways by conjugated bile acids.BMC Biochem. 2001; 2: 11
- Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes.Hepatology. 2002; 35: 779-789
- Ursodeoxycholic acid (UDCA) can inhibit deoxycholic acid (DCA)-induced apoptosis via modulation of EGFR/Raf-1/ERK signaling in human colon cancer cells.J. Nutr. 2004; 134: 483-486
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- Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes.Hepatology. 2002; 36: 49-54
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- Ursodeoxycholic acid inhibits the initiation and postinitiation phases of azoxymethane-induced colonic tumor development.Cancer Epidemiol. Biomarkers Prev. 2002; 11: 1316-1321
- Ursodeoxycholic acid prevents apoptosis of mouse sensory neurons induced by cisplatin by reducing P53 accumulation.Biochem Biophys Res Commun. 2008; 377: 1025-1030
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- Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: evidence for a mitochondrial pathway independent of the permeability transition.J. Neurochem. 2000; 75: 2368-2379
- Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease.Proc. Natl. Acad. Sci. USA. 2002; 99: 10671-10676
- Tauroursodeoxycholic acid improves the survival and function of nigral transplants in a rat model of Parkinson's disease.Cell Transplant. 2002; 11: 195-205
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- Amyloid β-peptide disrupts mitochondrial membrane lipid and protein structure: protective role of tauroursodeoxycholate.Biochem. Biophys. Res. Commun. 2001; 281: 468-474
- Tauroursodeoxycholic acid prevents E22Q Alzheimer's Aβ toxicity in human cerebral endothelial cells.Cell. Mol. Life Sci. 2009; 66: 1094-1104
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