- Chemnitius J.M.
- Winkel H.
- Meyer I.
- Schirrmacher K.
- Armstrong V.W.
- Kreuzer H.
- Zech R.
- Aviram M.
- Billecke S.
- Sorenson R.
- Bisgaier C.
- Newton R.
- Rosenblat M.
- Erogul J.
- Hsu C.
- Dunlop C.
- Du B. La
- Chemnitius J.M.
- Winkel H.
- Meyer I.
- Schirrmacher K.
- Armstrong V.W.
- Kreuzer H.
- Zech R.
- Chemnitius J.M.
- Winkel H.
- Meyer I.
- Schirrmacher K.
- Armstrong V.W.
- Kreuzer H.
- Zech R.
METHODS
Sample
PON1 genotype and activity measures
Lipid-related measurements
Statistical methods
RESULTS
| No Lipid-Lowering Medications | Taking Lipid-Lowering Medications | |||||
|---|---|---|---|---|---|---|
| CAAD (SD) | Non-CAAD (SD) | P | CAAD (SD) | Non-CAAD (SD) | P | |
| N | 91 | 184 | NA | 110 | 67 | NA |
| Caucasian | 100% | 100% | NA | 100% | 100% | NA |
| Male | 100% | 100% | NA | 100% | 100% | NA |
| Censored age mean (range), years | 67.0 (48–83) | 66.7 (47–83) | 0.87 | 65.3 (41–84) | 63.5 (50–80) | 0.17 |
| Current age mean (range), years | 70.4 (49–83) | 66.7 (47–83) | 0.002 | 69.6 (46–89) | 63.5 (50–80) | <0.001 |
| Lipid-lowering medications | 0% | 0% | NA | 100% | 100% | NA |
| Current smoker | 42% | 15% | <0.001 | 32% | 9% | 0.001 |
| Ever smoker | 92% | 74% | <0.002 | 95% | 68% | <0.001 |
| Type 2 diabetes | 15% | 17% | 0.73 | 22% | 16% | 0.44 |
| BMI | 26.6 (5.0) | 29.1 (6.3) | 0.001 | 28.4 (5.2) | 30.2 (4.7) | 0.020 |
| HDL-C mg/dl | 40.5 (14.0) | 46.9 (16.1) | 0.002 | 41.7 (14.2) | 41.4 (9.9) | 0.69 |
| HDL2 mg/dl | 8.1 (6.2) | 8.2 (5.8) | 0.45 | 7.0 (4.8) | 6.3 (3.2) | 0.36 |
| HDL3 mg/dl | 34.1 (13.7) | 37.7 (11.4) | <0.001 | 34.7 (10.0) | 35.2 (7.3) | 0.40 |
| ApoA-I | 121.3 (22.0) | 134.5 (24.5) | <0.001 | 120.5 (35.0) | 128.9 (16.3) | 0.11 |
| TG mg/dl | 159.4 (121.8) | 145.0 (97.6) | 0.13 | 180.9 (129.9) | 206.8 (193.2) | 0.40 |
| VLDL-C mg/dl | 31.9 (24.4) | 29.3 (21.3) | 0.14 | 36.1 (25.0) | 36.9 (24.8) | 0.68 |
| TC mg/dl | 197.1 (38.3) | 190.7 (37.0) | 0.12 | 186.6 (39.2) | 192.7 (41.3) | 0.30 |
| LDL-B mg/dl | 69.5 (17.4) | 65.8 (18.4) | 0.12 | 61.1 (16.2) | 64.5 (17.7) | 0.20 |
| LDL-C mg/dl | 106.4 (28.5) | 103.5 (30.0) | 0.38 | 89.2 (27.6) | 96.7 (30.6) | 0.10 |
| LDL density (Rf) mg/dl | 0.27 (0.03) | 0.26 (0.03) | 0.48 | 0.26 (0.03) | 0.24 (0.03) | 0.015 |
| Arylase units/l | 93.8 (42.4) | 106.1 (42.1) | 0.023 | 104.1 (41.8) | 117.0 (41.8) | 0.049 |
| DZOase units/l | 8,867.3 (3016.1) | 9,684.4 (3297.7) | 0.048 | 9,556.1 (3246.1) | 10,326.8 (2818.5) | 0.11 |
| POase units/l | 603.2 (424.1) | 673.0 (429.1) | 0.19 | 688.2 (484.6) | 653.0 (418.8) | 0.62 |
| PON1−162A MAF | 0.25 | 0.26 | 0.88 | 0.26 | 0.25 | 0.85 |
| PON1−108T MAF | 0.47 | 0.50 | 0.39 | 0.50 | 0.41 | 0.12 |
| PON155M MAF | 0.35 | 0.38 | 0.41 | 0.35 | 0.41 | 0.40 |
| PON1192R MAF | 0.30 | 0.31 | 0.97 | 0.32 | 0.25 | 0.13 |
| Arylase (adjusted Arylase) | DZOase (adjusted DZOase) | POase (adjusted POase) | |
|---|---|---|---|
| CAAD/non-CAAD No Lipid-Lowering Medications | |||
| Ln-HDL-C | −0.028/0.290 (−0.114/0.310) | 0.216/0.207 (0.060/0.296) | −0.177/0.162 (−0.026/0.241) |
| Ln-HDL2 | −0.039/0.184 (−0.104/0.219) | −0.004/0.099 (−0.098/0.191) | −0.035/0.141 (−0.016/0.169) |
| Ln-HDL3 | 0.113/0.330 (0.048/0.347) | 0.209/0.244 (0.171/0.342) | 0.107/0.178 (0.124/0.269) |
| ApoA-I | 0.025/0.329 (0.040/0.378) | 0.176/0.219 (0.196/0.375) | −0.046/0.218 (0.018/0.294) |
| Ln-TG | 0.301/−0.069 (0.347/−0.033) | 0.240/−0.019 (0.315/0.111) | 0.185/0.070 (0.328/0.064) |
| Ln-VLDL-C | 0.300/−0.066 (0.347/−0.030) | 0.239/−0.019 (0.315/0.111) | 0.184/0.070 (0.327/0.059) |
| Ln-cholesterol | 0.389/0.156 (0.416/0.204) | 0.297/0.157 (0.321/ 0.281) | 0.168/0.127 (0.290/0.292) |
| LDL-B | 0.307/0.024 (0.334/0.013) | 0.149/0.082 (0.178/0.068) | 0.132/0.045 (0.147/0.185) |
| LDL-C | 0.220/0.015 (0.243/0.019) | 0.062/0.079 (0.071/0.083) | 0.075/0.038 (0.092/0.181) |
| LDL density (Rf) | −0.262/0.008 (−0.316/-0.017) | −0.092/0.042 (−0.202/-0.017) | −0.237/−0.029 (−0.251/0.003) |
| CAAD/non-CAAD On LLM | |||
| Ln-HDL-C | −0.060/0.248 (−0.027/0.286) | 0.033/0.161 (0.098/0.124) | 0.147/0.149 (0.220/0.164) |
| Ln-HDL2 | −0.087/0.271 (−0.117/0.339) | −0.018/0.195 (−0.012/0.229) | 0.076/0.083 (0.091/0.158) |
| Ln-HDL3 | −0.049/0.213 (0.010/0.241) | 0.046/0.123 (0.136/0.069) | 0.171/0.152 (0.259/0.150) |
| ApoA-I | −0.166/0.226 (−0.139/0.285) | −0.064/0.052 (−0.007/0.059) | 0.011/0.216 (0.040/0.337) |
| Ln-TG | 0.150/0.021 (0.194/0.048) | 0.114/0.162 (0.139/0.237) | 0.023/−0.034 (0.002/0.178) |
| Ln-VLDL-C | 0.152/0.004 (0.195/0.001) | 0.116/0.148 (0.141/0.199) | 0.021/−0.072 (0.001/0.100) |
| Ln-cholesterol | 0.125/−0.007 (0.274/−0.069) | 0.085/0.142 (0.235/0.186) | 0.156/0.305 (0.131/0.263) |
| LDL-B | 0.113/−0.090 (0.292/−0.163) | 0.013/−0.019 (0.206/0.038) | 0.081/0.211 (0.042/0.053) |
| LDL-C | −0.016/−0.142 (0.181/−0.218) | −0.101/−0.034 (0.092/0.019) | 0.023/0.192 (−0.005/−0.043) |
DISCUSSION
Duan, X., W. Zhu, Z. Zhang, Y. Zhao, J. Dao, Y. Li, and Y. Xiao. 2004. The 1784 G > C polymorphism of sterol regulatory element binding protein-2 gene: prevalence and effect on serum lipid concentrations in hyperlipidemic individuals from China. J Lipid Res. Epub ahead of print. November 16, 2004; doi: 10.1194/jlr.M400166-JLR200.
Acknowledgments
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Published, JLR Papers in Press, July 1, 2005. DOI 10.1194/jlr.M400489-JLR200
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