Reducing saturated fat intake is associated with increased levels of LDL receptors on mononuclear cells in healthy men and women

REFERENCES

1. • Spady D.K
   • Dietschy J.M.
   Dietary saturated triacylglycerols suppress hepatic low density lipoprotein receptor activity in the hamster.
   Proc. Natl. Acad. Sci. USA. 1985; 82: 4526-4530
   • Google Scholar
2. • Spady D.K
   • Dietschy J.M.
   Interaction of dietary cholesterol and triacylglycerols in the regulation of hepatic low density lipoprotein transport in the hamster.
   J. Clin. Invest. 1988; 81: 300-309
   • Google Scholar
3. • Fernandez M.L.
   • McNamara D.J.
   Dietary fat-mediated changes in hepatic apoprotein B/E receptor in the guinea pig: effect of polyunsaturated, monounsaturated, and saturated fat.
   Metabolism. 1989; 38: 1094-1102
   • Google Scholar
4. • Fernandez M.L.
   • McNamara D.J.
   Regulation of cholesterol metabolism in guinea pigs is mediated by dietary fat quality and quantity.
   j. Nutr. 1991; 121: 934-943
   • Google Scholar
5. • Fernandez M.L.
   • Lin E.C.K.
   • McNamara D.J.
   Regulation of guinea pig plasma low density lipoprotein kinetics by dietary fat saturation.
   J. Lipid Res. 1992; 33: 97109
   • Google Scholar
6. • Fernandez M.L.
   • Abdel-Fattah G.
   • McNamara D.J.
   Dietary fat saturation modifies the metabolism of LDL subfractions in guinea pigs.
   Arterioscler. Thromb. 1993; 13: 1418-1428
   • Google Scholar
7. • Woollett L.A.
   • Spady D.K.
   • Dietschy J.M.
   Mechanisms by which saturated triacylglycerols elevate the plasma low density lipoprotein-cholesterol concentration in hamsters. Differential effects of fatty acid chain length.
   J. Clin. Invest. 1989; 84: 119-128
   • Google Scholar
8. • Woollett L.A.
   • Spady D.K.
   • Dietschy j.M.
   Saturated and unsaturated fatty acids independently regulate low density lipoprotein receptor activity and production rate.
   j. Lipid Res. 1992; 33: 77-88
   • Google Scholar
9. • Woollett L.A.
   • Spady D.K.
   • Dietschy j.M.
   Regulatory effects of the saturated fatty acids 6:0 through 18:0 on hepatic low density lipoprotein receptor activity in the hamster.
   j. Clin. Invest. 1992; 89: 1133-1141
   • Google Scholar
10. • Nicolosi R.J.
    • Stucchi A.F.
    • Kowala M.C.
    • Hennessy L.K.
    • Hegsted D.M.
    • Schaefer E.J.
    Effect of dietary fat saturation and cholesterol on LDL composition and metabolism.
    In vivo studies of receptor and nonreceptor-mediated catabolism of LDL in Cebus monkeys. Arterioscler. Thromb. 1990; 10: 119-128
    • Google Scholar
11. • Horton J.D.
    • Cuthbert J.A.
    • Spady D.K.
    Dietary fatty acids regulate hepatic low density lipoprotein (LDL) transport by altering LDL receptor protein and mRNA levels.
    j. Clin. Invest. 1993; 92: 743-749
    • Google Scholar
12. • Mustad V.A.
    • Ellsworth J.
    • Cooper A.D.
    • KrisEtherton P.M.
    • Etherton T.D.
    Dietary linoleic acid increases and palmitic acid decreases hepatic LDL receptor protein and mRNA abundance in young pigs.
    j. Lipid Res. 1996; 37: 2310-2323
    • Abstract
    • Full Text PDF
    • Google Scholar
13. • Ginsberg H.N.
    New directions in dietary studies and heart disease: the National Heart, Lung and Blood Institute sponsored Multicenter Study of Diet Effects on Lipoproteins and Thrombogenic Activity. In Nutrition and Biotechnology in Heart Disease and Cancer. JB Long-senecker, D. Kritchevsky, M. K. Drezner, editors. Plenum Press, New York.
    in: Kritchevsky D. Drezner M. K Liberation Ecologies: Environment, development, socialmovements. Plenum Press, New York1995: 241-247
    • Google Scholar
14. • Ho Y.K.
    • Brown M.S.
    • Bilheimer D.W.
    • Goldstein J.L.
    Regulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes.
    j. Clin. Invest. 1976; 58: 1465-1474
    • Google Scholar
15. • Biliheimer D.W.
    • Ho Y.K.
    • Brown M.S.
    • Anderson R.G.
    • Goldstein j.L.
    Genetics of the low density lipoprotein receptor.
    Diminished receptor activity in lymphocytes from heterozygotes with familial hypercholesterolemia.J. Clin. Invest. 1978; 61: 678-696
    • Google Scholar
16. • Cuthbert J.A.
    • Lipsky P.E.
    Identification of LDL receptor abnormalities by assaying functional receptors on proliferating lymphocytes.
    Arteriosclerosis. 1989; 9(suppl I): 143-149
    • Google Scholar
17. • Powell E.E.
    • Kroon P.A.
    Low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression in human mononuclear leukocytes is regulated coordinately and parallels gene expression in human liver.
    j. Clin. Invest. 1994; 93: 2168-2174
    • Google Scholar
18. • Mistry P.
    • Miller N.E.
    • Laker M.
    • Hazzard W.R.
    • Lewis B.
    Individual variation in the effects of dietary cholesterol on plasma lipoproteins and cellular cholesterol homeostasis in man. Studies of low density lipoprotein receptor activity and 3-hydroxy-3-methylglutaryl co-enzyme A activity in blood mononuclear cells.
    J. Clin. Invest. 1981; 67: 493-502
    • Google Scholar
19. • Applebaum-Bowden D.
    • Haffner S.M.
    • Hartsook E.
    • Luk K, H.
    • Hazzard J.J.
    • Albers W.R.
    Down-regulation of the low density lipoprotein receptor by dietary cholesterol.
    Am. J. Clin. Nutr. 1984; 39: 360-367
    • Google Scholar
20. • Leren T.P.
    • Hjermann I.
    • Maartmann-Moe K.
    • Beckmann S.L.
    • Leren P.
    • Berg K.
    Effect of lipid lowering diet on low density lipoprotein receptor activity in freshly isolated peripheral blood mononuclear cells.
    Acta Med. Scand. 1985; 218: 41-49
    • Google Scholar
21. • Lovati M.R.
    • Mansoni C.
    • Canavesi A.
    • Sirtori M.
    • Vac-carino V.
    • Marchi M.
    • Gaddi G.
    • Sirtori C.R.
    Soybean protein diet increases LDL receptor activity in mononuclear cells from hypercholesterolemic patients./. Clin.
    Invest. 1987; 80: 1498-1502
    • Google Scholar
22. • Roach P.D.
    • Hosking J.
    • Clifton P.M.
    • Bais R.
    • Kusenic B.
    • Coyle P.
    • Wight M.B.
    • Thomas D.W.
    • Nestel P.J.
    The effects of hypercholesterolaemia, simvastatin and dietary fat on the low density lipoprotein receptor of unstimulated mononuclear cells.
    Atherosclerosis. 1993; 103: 245245
    • Google Scholar
23. • Roach P.D.
    • Kerry N.L.
    • Whiting M.J.
    • Nestel P.J.
    Coordinate changes in the low density lipoprotein activity of liver and mononuclear cells in the rabbit.
    Atherosclerosis. 1993; 101: 157-164
    • Google Scholar
24. • Park S.
    • Snook j.T.
    Does a diet high in corn oil lower LDL cholesterol levels in women via an effect on LDL receptor activity.
    J. Nutr. Biochem. 1995; 6: 88-96
    • Google Scholar
25. • Sempos C.T.
    • Cleeman J.I.
    • Carroll M.D.
    • Johnson C.L.
    • Bachorik P.S.
    • Gordon D.J.
    • Burt V.L.
    • Briefel R.R.
    • Brown C.D.
    • Lippel K.
    Prevalence of high blood cholesterol among US adults. An update based on guidelines from the second report of the National Cholesterol Education Program Adult Treatment Panel.
    j. Am. Med. Assoc. 1993; 269: 3009-3014
    • Google Scholar
26. • Boyum A.
    Isolation of mononuclear cells and granulocytes from human blood. Scand.
    J. Clin. Lab. Invest. 1968; 97(suppl 21): 77-89
    • Google Scholar
27. • May K.
    • Kraemer F.B.
    • Chen K.
    • Cooper A.D.
    ELISA measurement of LDL receptors.
    J. Lipid Res. 1990; 31: 1683-1691
    • Google Scholar
28. • Kraemer F.B.
    • Sather S.A.
    • Park B.
    • Stalryd C.
    • Natu V.
    • May K.
    • Nishimura H.
    • Simpson I.
    • Cooper A.D.
    • Cushman S.W.
    Low density lipoprotein receptors in rat adipose cells: subcellular localization and regulation by insulin.
    J. Lipid Res. 1994; 35: 1760-1772
    • Google Scholar
29. • Ginsberg H.N.
    for the DELTA Study Investigators. 1995. Diet effects on lipids and thrombogenic activity: effects of reducing dietary total and saturated fat on plasma lipids and lipoproteins..
    FASEB J. 1995; 9
    • Google Scholar
30. • Shepherd J.P.
    • Packard C.J.
    • Gotto A.M.
    • Taunton O.D.
    The effects of dietary saturated and polyunsaturated fat on the metabolism of apolipoproteins AI and B. Study of a patient with type lib hyperlipopro-teinaemia.
    Clin. Chim. Acta. 1978; 87: 395-404
    • Google Scholar
31. • Shepherd J.P.
    • Packard C.J.
    • Patsch J.R.
    • Gotto A.M.
    • Taunton O.D.
    Effects of dietary polyunsaturated and saturated fat on the chemical composition and metabolism of low density lipoproteins in man.
    J. Lipid Res. 1980; 21: 91-99
    • Google Scholar
32. • Shi F.
    • Hurst P.G.
    • McNamara D.J.
    Increased degradation of LDL by mononuclear leukocytes associated with coronary artery disease.
    Atherosclerosis. 1990; 85: 127-137
    • Google Scholar
33. • Myant N.B.
    Cholesterol Metabolism, LDL, and the LDL receptors 467 LDL Receptor.
    Cholesterol Metabolism, LDL, and the LDL receptors 467 LDL Receptor. Academic Press, Inc., San Diego, CA.1990: 167-187
    • Google Scholar
34. • Hayes K.C.
    • Khosla P.
    Dietary fatty acid thresholds and cholesterolemia.
    FASEB J. 1992; 6: 2600-2607
    • Google Scholar
35. • Meddings J.B.
    • Dietschy j.M.
    Regulation of plasma levels of low-density lipoprotein cholesterol: interpretation of data on low-density lipoprotein turnover in man.
    Circulation. 1986; 74: 805-814
    • Google Scholar
36. • Brown M.S.
    • Goldstein J.L.
    A receptor-mediated pathway for cholesterol homeostatis.
    Science. 1986; 232: 34-47
    • Google Scholar
37. • Spady D.K.
    • Woollett L.A.
    • Dietschy j.M.
    Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids.
    Annu. Rev. Nutr. 1993; 13: 355-381
    • Google Scholar
38. • Kesaniemi Y.A.
    • Witztum J.L.
    • Steinbrecher U.P.
    Receptor-mediated catabolism of low density lipoprotein in man: quantitation using glycolylated low density lipoprotein.
    j. Clin. Invest. 1983; 71: 950-959
    • Google Scholar
39. • Soutar A.K.
    • Harders-Spengel K.
    • Wade D.
    • Knight B.
    Detection and quantitation of LDL receptors in human liver by ligand blotting, immunoblotting and radioimmunoassay.
    j. Biol. Chem. 1986; 261: 17127-17133
    • Google Scholar
40. • Cai H.-J.
    • Xie C.-L.
    • Chen Q.
    • Chen X.-Y.
    • Chen Y.-H.
    The relationship between hepatic low-density lipoprotein receptor activity and serum cholesterol levels in the human fetus.
    Hepatology. 1991; 13: 852-857
    • Google Scholar
41. • Schneider W.J.
    • Beisiegel U.
    • Goldstein J.L.
    • Brown M.S.
    Purification of the low density lipoprotein receptor, an acidic glycoprotein of 164,000 molecular weight.
    J. Biol. Chem. 1982; 257: 2664-2673
    • Google Scholar
42. • Distel R.J.
    • Robinson G.S.
    • Spiegelman B.M.
    Fatty acid regulation of gene expression. Transcriptional and post-transcriptional mechanisms.
    j. Biol. Chem. 1992; 267: 5937-5941
    • Google Scholar
43. • Keller H.
    • Dreyer C.
    • Medlin J.
    • Mahfoudi A.
    • Ozato K.
    • Wahli W.
    Fatty acids and retinoids control lipid metabolism through activation of peroxisome prolifera-tor-activated receptor and the glucocorticoid receptor.
    Proc. Natl. Acad. Sci. USA. 1993; 90: 2160-2164
    • Google Scholar
44. • Berdanier C.D.
    • Hargrove j.L.
    Nutrition and Gene Expression.
    Nutrition and Gene Expression. CRC Press, Inc., Boca Raton, FL.1993
    • Google Scholar
45. • Daumerie C.M.
    • Woollett L.A.
    • Dietschy j.M.
    Fatty acids regulate hepatic low density lipoprotein receptor activity through redistribution of intracellular cholesterol pools.
    Proc. Natl. Acad. Sci. USA. 1992; 89: 10797-10801
    • Google Scholar
46. • Rumsey S.C.
    • Galeano N.F.
    • Lipschitz B.
    • Deckelbaum R.J.
    Oleate and other long chain fatty acids stimulate low density lipoprotein receptor activity by enhancing acyl coenzyme A: cholesterol acyl transferase activity and altering intracellular regulatory cholesterol pools in cultured cells.
    j. Biol. Chem. 1995; 270: 10008-10016
    • Google Scholar
47. • Wang X.
    • Sato R.
    • Brown M.S.
    • Hua X.
    • Goldstein J.L.
    SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis.
    Cell. 1994; 77: 53-62
    • Google Scholar
48. • Wang S.
    • Zelenski N.G.
    • Yang J.
    • Sakai J.
    • Brown M.S.
    • Goldstein j.L.
    Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.
    EMBO J. 1996; 15: 1012-1020
    • Google Scholar