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Research Articles| Volume 3, ISSUE 4, P397-404, October 01, 1962

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Turnover of deoxycholic acid in the rabbit*

Open AccessPublished:October 01, 1962DOI:https://doi.org/10.1016/S0022-2275(20)40380-3
Turnover of deoxycholic acid in the rabbit*
Next ArticleInfluence of semisynthetic diet and type of fat on the turnover of deoxycholic acid in the rabbit*
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      A method for studying the turnover of deoxycholic acid in the rabbit is described. The mean values for half-life, pool size, and daily production of deoxycholic acid were 6.8 days, 700 mg, and 73.4 mg, respectively, in 26 rabbits on a diet of conventional commercial food pellets. Of the bile acid pool, 97–98% was present in liver, gallbladder, and gastro-intestinal tract. A comparatively large amount (10%) was present in the stomach. Fecal excretion was the main excretory pathway for bile acids. An amount corresponding to 10% of the daily synthesis of deoxycholic acid was excreted in the urine. The concentration of bile acids in blood was calculated to be 0.26–3.10 mg/100 ml of whole blood.

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      Article info

      Publication history

      Published online: October 01, 1962
      Received: June 20, 1962

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      DOI: https://doi.org/10.1016/S0022-2275(20)40380-3

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      © 1962 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.

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