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Research Article| Volume 33, ISSUE 5, P627-633, May 1992

Effect of dietary oils on lipid peroxidation and on antioxidant parameters of rat plasma and lipoprotein fractions.

Open AccessPublished:May 01, 1992DOI:https://doi.org/10.1016/S0022-2275(20)41427-0
Effect of dietary oils on lipid peroxidation and on antioxidant parameters of rat plasma and lipoprotein fractions.
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      In order to investigate the influence of fatty acid pattern and antioxidants other than vitamin E on lipid peroxidation and antioxidant levels of plasma very low density and low density lipoproteins (VLDL + LDL), the effects of three diets (equalized for vitamin E) containing soybean oil, olive oil, or an oleate-rich mixture of triglycerides (triolein) were studied in rats. A significantly lower concentration of thiobarbituric acid-reactive substances (TBA-RS) in plasma and lipoproteins was found after the olive oil diet (soybean oil, 3.7 +/- 0.4 nmol/ml; triolein, 2.1 +/- 0.5 nmol/ml; olive oil, 1.5 +/- 0.3 nmol/ml, in plasma) (soybean oil, 0.99 +/- 0.16 nmol/ml; triolein, 0.96 +/- 0.13 nmol/ml; olive oil, 0.38 +/- 0.12 nmol/ml, in the VLDL + LDL fraction). Furthermore, the results from in vitro copper-induced lipid peroxidation, expressed in terms of conjugated dienes, lipid hydroperoxides, and TBA-RS content, showed that VLDL + LDL particles from olive olive oil-fed rats were remarkably resistant to oxidative modification. The results suggest that the fatty acid unsaturation of dietary oils is not the only determining factor of the antioxidant capacity of lipoproteins in this animal model. The maximal protection observed after the olive oil diet may be explained by the presence of other unidentified antioxidants in addition to vitamin E, derived from oil intake. Therefore, the optimal balance between the content of unsaturated fatty acids and natural antioxidants in dietary oils appears to be of major importance.

      REFERENCES

        • Draper H.H.
        Nutritional modulation of oxygen radical pathology.
        Adv. Nutr. Res. 1990; 8: 119-145
        • Steinberg D.
        • Parthasarathy S.
        • Carew T.E.
        • Khoo J.C.
        • Witztum J.L.
        Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity.
        N. Engl. J. Med. 1989; 320: 915-924
        • Quinn M.T.
        • Parthasarathy S.
        • Fong L.G.
        • Steinberg D.
        Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis.
        Proc. Natl. Acad. Sci. USA. 1987; 84: 2995-2998
        • Steinbrecher U.P.
        • Zhang H.
        • Lougheed M.
        Role of oxidatively modified LDL in atherosclerosis.
        Free Rad. Biol. Med. 1990; 9: 155-168
        • Heinecke J.W.
        Free radical modification of low-density lipoprotein: mechanisms and biochemical consequences.
        Free Rad. Biol. Med. 1987; 3: 65-73
        • Faggiotto A.
        • Ross R.
        Studies on hypercholesterolemia in the nonhuman primate. II. Fatty streak conversion to fibrous plaque.
        Arteriosclerosis. 1984; 4: 341-356
        • Palinsky W.
        • Rosenfeld M.E.
        • Yla-Herttuala S.
        • Gurtner G.C.
        • Socher S.S.
        • Butler S.W.
        • Parthasarathy S.
        • Carew T.E.
        • Steinberg D.
        • Witztum J.L.
        Low density lipoprotein undergoes oxidative modification in vivo.
        Proc. Natl. Acad. Sci. USA. 1989; 86: 1372-1376
        • Avogaro P.
        • Bittolo-Bon G.
        • Cazzolato G.
        Presence of a modified low density lipoprotein in human.
        Arteriosclerosis. 1988; 8: 79-87
        • Parthasarathy S.
        • Khoo J.C.
        • Miller E.
        • Barnett J.
        • Witztum J.
        • Steinberg D.
        Low density lipoprotein rich in oleic acid is protected against oxidative modification: Implications for dietary prevention of atherosclerosis.
        Proc. Natl. Acad. Sci. USA. 1990; 87: 3894-3898
        • Jessup W.
        • Rankin S.M.
        • De Whalley C.
        • Hoult J.R.S.
        • Scott J.
        • Leake D.S.
        Alpha- tocopherol consumption during low-density-lipoprotein oxidation.
        Biochem. J. 1990; 265: 399-405
        • Hessler J.R.
        • Morel D.W.
        • Lewis L.J.
        • Chisolm G.M.
        Lipoprotein oxidation and lipoprotein-induced cytotoxicity.
        Arteriosclerosis. 1983; 3: 215-222
        • Morel D.W.
        • Hessler J.R.
        • Chisolm G.M.
        Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipids.
        J. Lipid Res. 1983; 24: 1070-1076
        • Chapman M.J.
        Animal lipoproteins: chemistry, structure and comparative aspects.
        J. Lipid Res. 1980; 21: 789-853
        • Metcalfe L.D
        • Schmitz A.A.
        Rapid preparation of fatty acid ester for gas-chromatography analysis.
        Anal. Chem. 1961; 33: 363-369
        • Carpenter A.P.
        Determination of tocopherol in vegetable oils.
        J. Am. Oil Chem. Soc. 1979; 56: 668-671
        • McMurray C
        • Blauchflower W.J.
        • Rice D.A.
        Influence of extraction techniques on determination of alpha-tocopherol in animal foodstuff.
        J. Assoc. Off. Anal. Chem. 1980; 63: 1258-1261
        • Havel R.J.
        • Eder H.A.
        • Bradgon J.H.
        The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum.
        J. Clin. Invest. 1955; 34: 1345-1353
        • Lasser N.L.
        • Roheim P.S.
        • Edelstein D.
        • Eder H.A.
        Serum lipoproteins of normal and cholesterol-fed rats.
        J. Lipid Res. 1973; 14: 1-8
        • Bieri J.G.
        • Tolliver T.J.
        • Catignani G.L.
        Simultaneous determination of alpha-tocopherol and retinol in plasma or red cells by high pressure liquid chromatography.
        Am. J. Clin. Nutr. 1979; 32: 2143-2149
        • Stacewicz-Sapuntzakis M.
        • Bowen P.E.
        • Kikendall J.W.
        • Burgess M.
        Simultaneous determination of serum retinol and various carotenoids: their distribution in middle-aged men and women.
        J. Micronutr. Anal. 1987; 3: 27-45
        • Farber C.M.
        • Kanengiser S.
        • Stahl R.
        • Liebes L.
        • Silber R.
        A specific high-performance liquid chromatography assay for dehydroascorbic acid shows an increased content in CLL lymphocytes.
        Anal. Biochem. 1983; 134: 355-360
        • Iversen S.A.
        • Cawood P.
        • Dormandy T.L.
        A method for the measurement of a diene-conjugated derivative of linoleic acids, 18:2 (9, 11), in serum phospholipid, and a possible origin.
        Ann. Clin. Biochem. 1985; 22: 137-140
        • Yagi K.
        Assay for serum lipid peroxide level and its clinical significance.
        in: Yagi K. Lipid Peroxide in Biology and Medicine. Academic Press, New York1982: 324-340
        • Maseki M.
        • Nishigaki I.
        • Hagihara M.
        • Tomoda Y.
        • Yagi K.
        Lipid peroxide levels and lipid content of serum lipoprotein fractions of pregnant subjects with or without pre-eclampsia.
        Clin. Chim. Acta. 1981; 115: 155-161
        • Ellman G.L.
        Tissue sulphydryl groups.
        Arch. Biochem. Biophys. 1959; 82: 70-77
        • Mueller H.W
        • Binz K.
        Glass capillary gas chromatography of the serum fatty acid fraction via automatic injection of lipid extracts.
        J. Chromatog. 1982; 288: 75-93
        • Knapp D.R.
        Handbook of Analytical Derivatization Reactions. J. Wiley & Sons., New York1979: 151-152
        • Wayner D.D.M.
        • Burton G.W.
        • Ingold K.W.
        • Barclay L.R.C.
        • Locke S.L.
        The relative contribution of vitamin E, urate, ascorbate and proteins to the radical-trapping antioxidant activity of human blood samples.
        Biochim. Biophys. Acta. 1987; 924: 408-419
        • Steinbrecher V.P.
        • Witztum J.
        • Parthasarathy S.
        • Steinberg D.
        Decrease in reactive ami no groups during oxidation or endotelian cell modification of LDL.
        Arteriosclerosis. 1987; 7: 135-143
        • El-Saadani M.
        • Esterbauer H.
        • El-Sayed M.
        • Goher M.
        • Nassar A.Y.
        • Jürgens G.
        A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent.
        J. Lipid Res. 1989; 30: 627-630
        • Esterbauer H.
        • Schaur R.J.
        • Zollner H.
        Chemistry and biochemistry of 4-hydroxynonenal, malon-aldehyde and related aldehydes.
        Free Rod. Biol. Med. 1991; 11: 81-128
        • Babiy A.V.
        • Gebicki J.M.
        • Sullivan D.R.
        Vitamin E content and low density lipoprotein oxidizability induced by free radicals.
        Atherosclerosis. 1990; 81: 175-182
        • Esterbauer H.
        • Dieber-Rotheneder M.
        • Waeg G.
        • Puhl H.
        • Tatzber F.
        Endogenous antioxidants and lipoprotein oxidation.
        Biochem. Soc. Trans. 1990; 18: 1059-1061
        • Dieber-Rotheneder M.
        • Puhl H.
        • Waeg G.
        • Streigl G.
        • Esterbauer H.
        Effect of oral supplementation with D-a-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation.
        J. Lipid Res. 1991; 32: 1325-1332
        • Stocker R.
        • Bowry V.W.
        • Frei B.
        Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation that does cx-tocopherol.
        Proc. Natl. Acad. Sci. USA. 1991; 88: 1646-1650
        • Ursini F.
        • Pelosi G.
        • Tomassi G.
        • Benassi A.
        • Di Felice M.
        • Barsacchi R.
        Effect of dietary fats on hydroperoxide-induced chemiluminescence emission and eicosanoic release in the rat heart.
        Biochim. Biophys. Ada. 1987; 919: 93-96
        • Fedeli E.
        Lipids of olives.
        Prog. Chem. Fats Other Lipids. 1977; 15: 57-74
        • Kiritsakis A.
        • Markakis P.
        Olive oil: a review.
        Adv. Food Res. 1987; 31: 453-482
        • Gutfinger H.
        Polyphenols in olive oil.
        J. Am. Oil Chem. Soc. 1981; 58: 966-968
        • Boskou D.
        • Morton I.D.
        Changes in sterol composition of olive oil on heating.
        J. Sci. Food Agric. 1975; 26: 1149-1153
        • Di Mascio P.
        • Murphy M.E.
        • Sies H.
        Antioxidant defence system: the role of carotenoids, tocopherols and thiols.
        Am. J. Clin. Nutr. 1991; 53: 194S-200S
        • Simpson K.L.
        Relative value of carotenoids as precursors of vitamin A..
        Proc. Nutr. Soc. 1983; 42: 7-17

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      Published online: May 01, 1992

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      DOI: https://doi.org/10.1016/S0022-2275(20)41427-0

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