JLR Commentaries
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- CommentaryOpen Access
Life is complicated: so is apoCIII
Journal of Lipid ResearchVol. 60Issue 8p1347–1349Published online: June 25, 2019- Gissette Reyes-Soffer
- Henry N. Ginsberg
Cited in Scopus: 5Apolipoprotein (apo)CIII, comprised of 79 amino acids and with a mass of 8.8 kDa, was first isolated and characterized 50 years ago by Brown et al. (1). Studies conducted during the following decade demonstrated that apoCIII was an inhibitor of both LPL (2) and the uptake of triglyceride-rich lipoproteins (TGRLs) and remnants by perfused livers (3, 4). Lipoprotein kinetic studies of two sisters with complete absence of apoCIII (5) demonstrated, in vivo, that absence of this protein resulted in a dramatic increase in lipolysis of VLDL-TG (6).
