JLR Commentaries
De(C1P)hering the role of ceramide-1-phosphate levels in skin wound healing
The skin is the largest organ of the body and serves several important roles: preventing water loss, serving as the first barrier against trauma—including UV radiation and chemicals—and pathogens, participating in metabolic functions such as vitamin D synthesis and temperature regulation, and informing the body of external conditions through billions of sensory and proprioceptor nerve cells. It is a dynamic organ composed of various cell types that have specific and unique functions, which are present in different skin layers, called the epidermis, dermis, and hypodermis.Lipid signaling in keratinocytes: Lipin-1 plays a PArt
Although it is well recognized that lipids play an important role in providing the structural barriers that delineate the cell and its various organelles, accumulating evidence also points to the critical involvement of lipids in cell signaling. Unlike some signaling molecules, however, an understanding of lipids as signals must take into account the additional intricacy afforded by the fact that many lipid signals can be interconverted. For example, diacylglycerol (DAG), a lipid known to activate enzymes such as protein kinases and guanine nucleotide exchange factors, can be phosphorylated by diacylglycerol kinase to yield phosphatidic acid (PA), which has its own effector enzymes (Fig.
