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  • Commentary
    Open Access

    HDL and pancreatic β cells: a SMO-king gun?

    Journal of Lipid Research
    Vol. 61Issue 4p468–469Published online: January 7, 2020
    • Liam R. Brunham
    Cited in Scopus: 1
      Levels of HDL cholesterol (HDL-C) are inversely correlated with risk of diabetes mellitus (1), and administration of reconstituted HDL to patients with diabetes mellitus enhances β-cell function (2). HDL protects β cells from apoptosis and inhibits the pro-apoptotic effects of LDL on islets (3). How HDL exerts these beneficial effects on β cell survival and function is unknown, but it has been hypothesized that these effects are mediated by ATP transporters, known to be critical for β-cell function (4, 5), or, alternatively, via an effect of HDL on the subcellular distribution of cholesterol and its metabolites and their interactions with various cellular receptors.

    ASBMB  ASBMB  ASBMB  ASBMB

    ISSN 0022-2275
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