x
Filter:
Filters applied
- Commentaries
- Ciorba, Matthew ARemove Ciorba, Matthew A filter
- Journal of Lipid ResearchRemove Journal of Lipid Research filter
JLR Commentaries
1 Results
- CommentaryOpen Access
Scap and the intestinal epithelial stem cell niche: new insights from lipid biology
Journal of Lipid ResearchVol. 56Issue 8p1381–1382Published online: June 10, 2015- Matthew A. Ciorba
Cited in Scopus: 1SCAP is required for proteolytic cleavage and activation of sterol regulatory element-binding proteins (SREBPs). Once activated, SREBPs translocate to the nucleus to initiate transcription of genes required for fatty acid and sterol synthesis. Liver specific Scap deletion protects mice from fatty liver and carbohydrate-induced hypertriglyceridemia (1). As such, SCAP inhibition is a potential therapeutic target for disorders linked to hyperlipidemia and hepatic steatosis. Both statins and ezetimibe increase the abundance of nuclear SREBP and provoke a compensatory increase in intestinal cholesterol synthesis.
