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JLR Commentaries
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- CommentaryOpen Access
Long-lost friend is back in the game
Journal of Lipid ResearchVol. 62100072Published online: April 1, 2021- Sander Kersten
Cited in Scopus: 0Triglycerides (TGs) are transported in the bloodstream by TG-rich lipoproteins in the form of chylomicrons and VLDLs. The hydrolysis of circulating TGs is rate-limiting for their uptake into tissues and is catalyzed by the enzyme lipoprotein lipase (LPL) (1). The activity of LPL in different tissues is extensively regulated to be able to adjust to changes in lipid availability and demand. The regulation of LPL is mainly carried out at the posttranslational level and is mediated by two groups of proteins.