JLR Commentaries
COVID-19: lipid disruption is pushing the envelope
A plethora of articles have been published on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and science has delivered, given the rapid development of vaccines and of novel antiviral therapeutics evaluated for their efficacy efficiently in platform trials. An unfolding story of interferon genetics and autoantibodies has begun to help us parse the reasons for varied susceptibility to severe disease and sequencing, and tracking at a global level has allowed for the rapid detection of new variants as they emerge.De(C1P)hering the role of ceramide-1-phosphate levels in skin wound healing
The skin is the largest organ of the body and serves several important roles: preventing water loss, serving as the first barrier against trauma—including UV radiation and chemicals—and pathogens, participating in metabolic functions such as vitamin D synthesis and temperature regulation, and informing the body of external conditions through billions of sensory and proprioceptor nerve cells. It is a dynamic organ composed of various cell types that have specific and unique functions, which are present in different skin layers, called the epidermis, dermis, and hypodermis.HDL, heart disease, and the lung
For more than 50 years, a low plasma level of HDL-cholesterol has been known as an independent risk factor of atherosclerotic cardiovascular diseases (ASCVD). In addition, HDL particles exert a plethora of potentially anti-atherogenic activities on many cells including endothelial cells, smooth muscle cells, as well as monocyte-derived macrophages and other inflammatory cells. Nevertheless, therapeutic interventions raising HDL-cholesterol did not improve the prevention of cardiovascular events beyond standard therapy with statins.
