INTRODUCTION
• Overview of the JLR publication process
• Editorial policies
• Types of article
• Submission checklist
BEFORE YOU BEGIN
• Ethics in publishing
• Studies involving human subjects or animals
• Informed consent and patient details
• Declaration of interest
• Submission declaration and verification
• Use of inclusive language
• Reporting sex- and gender-based analyses
• Changes to authorship
• Clinical trial results
• Copyright
• Role of the funding source
• Open Access
PREPARATION
• Submission
• Queries
• Article structure
• Artwork
• Preparing supplemental data
• Cover letter
• Resubmissions
AFTER ACCEPTANCE
• Online proof correction
AUTHOR INQUIRIES




Overview of the JLR publication process

For initial submission, authors should provide their manuscript as a Word file used to prepare the text and tables as well as publication quality figures. Our online submission tool will combine these files into a single PDF. Along with the manuscript PDF file, the authors may submit a Cover Letter and any allowable supplemental data files on the submission site.

Authors will be notified by the Associate Editor as to whether their manuscript has been accepted, declined, or a revision requested. Please see here for more information regarding JLR's peer review process. If a revision is requested, authors should prepare and submit a revised manuscript for review. In addition to the manuscript PDF and any supplementary information files, authors will be asked to upload all source files (i.e., the Word file for the text and tables and the publication quality figures). If the manuscript is accepted for publication, the manuscript PDF will be published as a Paper in Press within 24 hours of acceptance.

Scope

The Journal of Lipid Research (JLR) publishes original articles and reviews in the broadly defined area of biological lipids. The submission of manuscripts relating to lipids, including those addressing problems in biochemistry, molecular biology, structural biology, cell biology, genetics, molecular medicine, clinical medicine, and metabolism is encouraged. Along with sound primary experimental data, major criteria for acceptance of articles are new insights into mechanisms of lipid function and metabolism and/or genes regulating lipid metabolism. Interpretation of the data is the authors' responsibility, and speculation should be labeled as such. Manuscripts that provide new ways of purifying, identifying, and quantifying lipids are invited for the Methods section of the Journal.

Peer review process

Provided that submissions are within the aim and scope of the Journal, manuscripts are assigned by the Editor-in-Chief to an Associate Editor. The Associate Editor sends the submitted manuscript out for evaluation by at least two reviewers. Reviewers are assigned by the Associate Editor handling the manuscript. The Associate Editor makes a decision for acceptance, revision, or declination based not only on reviewer comments, but also whether the manuscript provides new and exciting information that is the high quality expected by JLR.

The identity of all reviewers remains unknown to the authors. Every manuscript is treated by the Editors and reviewers as privileged information, and they are instructed to exclude themselves from the review of any manuscript that might involve a conflict of interest or the appearance thereof. During initial submission, prospective authors are encouraged to recommend one or more Associate Editors who would be particularly appropriate to handle their manuscript. Authors cannot exclude Associate Editors. Authors are also given an opportunity to suggest (and exclude) potential referees with the expertise needed to evaluate the manuscript.

Authorship criteria

Adapted from the recommendation of the International Committee of Medical Journal Editors (ICMJE)

Authorship credit should be based on the following:
  1. substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data;
  2. drafting the article or substantively contributing to revisions in intellectual content;
  3. final approval of the version to be published;
  4. agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.


All those designated as authors must meet all four criteria for authorship. Acquisition of funding or general supervision of the research group alone does not constitute authorship. It is expected that each author has made an important scientific contribution to the study and is thoroughly familiar with the original data. It is also expected that each author has read the complete manuscript and takes responsibility for its content and completeness. By accepting authorship, the author understands that if the paper, or any part thereof, is found to be faulty or in violation of ethical standards, they share responsibility with their co-authors.

Assignment of each author's contributions is requested as part of the online submission process.

"Group authorship" is allowed in which the name of the consortium or program is listed as an author, with members of the group listed in the Acknowledgments section. All listed members must meet the full criteria and requirements for authorship as described.

The Editor-in-Chief maintains discretion to allow or disallow inclusion of authors who are deceased. To facilitate review in each case, the contributions of these authors should be described in detail in the manuscript cover letter and within the online submission system.

All substantial changes in authorship (additions, removals, or change in order) that are requested after acceptance must be approved by the Associate Editor and all co-authors. Requests for changes must be made by the corresponding author, co-signed by all co-authors, and sent to the Associate Editor who handled the manuscript. For any requests to remove a co-author, the person who will be removed must also send a letter to the Associate Editor acknowledging this change.

ASBMB journals follow the ICJME recommendations for responsibilities of the corresponding author.

Contact us

If you have any questions related to your current manuscript or past publication in the journal, please contact our editorial office at .

Editorial policies

Please click here to see the shared editorial policies for the three ASBMB journals.

Types of article

Regular research articles

These articles present original research and address a clearly stated specific hypothesis or question. Papers should provide novel approaches and new insights into the problem addressed. Manuscripts dealing with mechanisms are especially encouraged. More descriptive, "stamp collecting" studies are generally not suitable for publication in the Journal unless judged to provide fundamental insights or fundamental baseline contributions to lipid biology or biochemistry.

Manuscripts in which lipidomic, proteomic and/or genomic analytical techniques are used to assess lipid and/or lipoprotein moieties in various metabolic settings, both in vitro and in vivo, must provide the reasons for the observed changes in lipid moieties.

Manuscripts that explore nutrition or food science as it relates to lipids must present studies that (a) utilize and compare individual nutrients that are very well-defined chemically and (b) include a well-developed mechanistic component clearly relating each nutritional additive to a biological outcome(s).

Methods articles

The Editors will consider significant new/novel contributions in the field of lipid methodology; the paper must provide sufficient details so that the method can be readily reproduced. These papers should be short and concise. Manuscripts describing methods that can be used in analyzing lipids in a biological context and are likely to be of broad utility in the lipid community are the most attractive to the Journal. Papers describing complex chemical syntheses of lipids are usually better suited for a more specialized journal.

Patient-oriented and epidemiological research articles

These studies are those in which human subjects are the dominant focus of the manuscript. These manuscripts must include a statement of institutional approval of the study and adherence to the Declaration of Helsinki principles. This type of study could include a classical clinical investigation in which one of the authors has had direct contact with the subjects, an investigation in which samples collected from a human study were studied by the authors, a genetic analysis of human subjects, or a novel analysis of existing large-scale genetic biobanks. To be considered in this category, the study must make connections between the results and the human sources of the samples (individuals or groups). It does not matter whether the samples were subsequently used in an in vivo, ex vivo, or in vitro analysis.

Images in Lipid Research

These submissions are one-page articles that contain a single horizontal figure, a 100-word description with a maximum of up to three references, and no more than four authors. The figure and description must convey a mechanistic point about lipid metabolism. Figures may be micrographs, protein structures, and/or lipid molecules. Clinical photographs or images of diagnostic test will also be considered. The images used in the figure must be original and free of copyrighted content that has been submitted or published elsewhere. The following items are required at submission:
  • A Word document of up to 100-words and a maximum of 3 references that explains the significance of the image is required. The title should be no longer than 15 words and should be non-technical. The reagents and equipment used to generate the image should be provided as a separate paragraph with a maximum of 40 words following the main text. References should be formatted the same as a regular research article. A figure legend should not be included. The Author Acknowledgements and the Conflict of Interest statement should not exceed a maximum of 40 words.
  • A figure file as either a tiff or eps file must be uploaded to the submission system. The image must be horizontal with a width:height ratio of 2:1(Width, 318 pixels; Height, 205 pixels; Resolution, 300 dpi). Fluorescent images must show signals from individual channels in gray scale to reveal the full dynamic range of intensities and to allow color-blind individuals to appreciate the image. Merged images should be presented in color, with distinct colors for individual channels.


Review articles

The Journal publishes critical reviews on current, timely topics. Reviews should be concise and should provide a balanced analysis and summary of the topic. The information should be understandable to scientists in other related fields. A good and critical review will develop new insights into the field and propose potential new research opportunities. The Journal generally invites reviews written by established investigators in the field, although an unsolicited review from an expert in the field may be published if the review is judged to be exceptionally timely, topical, novel, and of broad interest to JLR readers.

Submission checklist

You can use this list to carry out a final check of your submission before you send it to the journal for review. Please check the Article Structure section in this Guide for Authors for more details.

Please consult the detailed list to ensure that the following key items are present:
  • Corresponding author information
  • Submission files:


  • Mandatory items
    • Article title
    • co-Author names and affiliations
    • Section titles
    • All figures as individual high-resolution files. Legends should be supplied within the manuscript file.
    • All tables as individual files. All titles, description and footnotes should be provided within the manuscript file.
    • Ensure all figure and table citations in the manuscript text match the files provided.
    • Author CRediT statement (the template file will be provided during submission)


    Optional items
    • Graphical abstract
    • Supplemental files


    Other considerations:

    Please double check the following:
    • Manuscript has been "spell checked" and "grammar checked." You may consider Language Editing services or any other service of your choice if needed.
    • All references mentioned in the Reference List are cited in the text, and vice versa.
    • Permission has been obtained for use of copyrighted material from other sources (including the Internet).
    • A Declaration of Interest is provided, even if the authors have no competing interests to declare.
    • Journal policies detailed in this guide have been reviewed.
    • Referee suggestions and contact details provided, based on journal requirements.


    For further information, visit our Support Center. We recommend you use the Chat option at the bottom of the page for immediate help. If you need additional help, please contact our editorial office at .




    Ethics in publishing

    Please see our information on Ethics in publishing.

    Studies involving human subjects or animals

    Human subjects

    All studies involving human subjects must be approved by the appropriate review board(s) and abide by the Declaration of Helsinki principles. A specific statement declaring approval and Helsinki compliance must be included in the Experimental Procedures section. Published studies that involve human subjects should not provide any identifying information (e.g., names, true initials, recognizable images) unless the information is essential for scientific purposes and the patient (or patient's parent/guardian) gives written informed consent for publication. If the patient is deceased, then the authors should seek consent from a relative. If such written consent is required, please download the form here and upload as additional Supplemental material for review only.

    Animal and preclinical research studies

    ASBMB encourages the reporting of animal data using the nomenclature and standards outlined in the ARRIVE (Animal in Research: Reporting In Vivo Experiments) guidelines, Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research PLoS Biol. 2010 Jun 29;8(6):e1000412. All studies must be approved by the appropriate review board(s) and a specific statement of such an approval must be made in the Experimental Procedures section.

    Informed consent and patient details

    Studies on patients or volunteers require ethics committee approval and informed consent, which should be documented in the paper. Appropriate consents, permissions and releases must be obtained where an author wishes to include case details or other personal information or images of patients and any other individuals in an Elsevier publication. Written consents must be retained by the author but copies should not be provided to the journal. Only if specifically requested by the journal in exceptional circumstances (for example if a legal issue arises) the author must provide copies of the consents or evidence that such consents have been obtained. For more information, please review the Elsevier Policy on the Use of Images or Personal Information of Patients or other Individuals. Unless you have written permission from the patient (or, where applicable, the next of kin), the personal details of any patient included in any part of the article and in any supplementary materials (including all illustrations and videos) must be removed before submission.

    Declaration of interest

    All authors must disclose any financial and personal relationships with other people or organizations that could inappropriately influence (bias) their work. Examples of potential competing interests include employment, consultancies, stock ownership, honoraria, paid expert testimony, patent applications/registrations, and grants or other funding. Authors must disclose any interests in two places: 1. A summary declaration of interest statement in the title page file (if double anonymized) or the manuscript file (if single anonymized). If there are no interests to declare then please state this: 'Declarations of interest: none'. 2. Detailed disclosures as part of a separate Declaration of Interest form, which forms part of the journal's official records. It is important for potential interests to be declared in both places and that the information matches. More information.

    Please find Declaration of Interest form here.

    Submission declaration and verification

    Submission of an article implies that the work described has not been published previously (except in the form of an abstract, a published lecture, academic thesis, or preprint, see 'Multiple, redundant or concurrent publication' for more information), that it is not under consideration for publication elsewhere, that its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work was carried out, and that, if accepted, it will not be published elsewhere in the same form, in English or in any other language, including electronically without the written consent of the copyright-holder. To verify originality, your article may be checked by the originality detection service Crossref Similarity Check.

    Preprints

    Please note that preprints can be shared anywhere at any time, in line with Elsevier's sharing policy. Sharing your preprints e.g. on a preprint server will not count as prior publication (see 'Multiple, redundant or concurrent publication' for more information).

    Use of inclusive language

    Inclusive language acknowledges diversity, conveys respect to all people, is sensitive to differences, and promotes equal opportunities. Content should make no assumptions about the beliefs or commitments of any reader; contain nothing which might imply that one individual is superior to another on the grounds of age, gender, race, ethnicity, culture, sexual orientation, disability or health condition; and use inclusive language throughout. Authors should ensure that writing is free from bias, stereotypes, slang, reference to dominant culture and/or cultural assumptions. We advise to seek gender neutrality by using plural nouns ("clinicians, patients/clients") as default/wherever possible to avoid using "he, she," or "he/she." We recommend avoiding the use of descriptors that refer to personal attributes such as age, gender, race, ethnicity, culture, sexual orientation, disability or health condition unless they are relevant and valid. When coding terminology is used, we recommend to avoid offensive or exclusionary terms such as "master", "slave", "blacklist" and "whitelist". We suggest using alternatives that are more appropriate and (self-) explanatory such as "primary", "secondary", "blocklist" and "allowlist". These guidelines are meant as a point of reference to help identify appropriate language but are by no means exhaustive or definitive.

    Reporting sex- and gender-based analyses

    Reporting guidance
    For research involving or pertaining to humans, animals or eukaryotic cells, investigators should integrate sex and gender-based analyses (SGBA) into their research design according to funder/sponsor requirements and best practices within a field. Authors should address the sex and/or gender dimensions of their research in their article. In cases where they cannot, they should discuss this as a limitation to their research's generalizability. Importantly, authors should explicitly state what definitions of sex and/or gender they are applying to enhance the precision, rigor and reproducibility of their research and to avoid ambiguity or conflation of terms and the constructs to which they refer (see Definitions section below). Authors can refer to the Sex and Gender Equity in Research (SAGER) guidelines and the SAGER guidelines checklist. These offer systematic approaches to the use and editorial review of sex and gender information in study design, data analysis, outcome reporting and research interpretation - however, please note there is no single, universally agreed-upon set of guidelines for defining sex and gender.

    Definitions
    Sex generally refers to a set of biological attributes that are associated with physical and physiological features (e.g., chromosomal genotype, hormonal levels, internal and external anatomy). A binary sex categorization (male/female) is usually designated at birth ("sex assigned at birth"), most often based solely on the visible external anatomy of a newborn. Gender generally refers to socially constructed roles, behaviors, and identities of women, men and gender-diverse people that occur in a historical and cultural context and may vary across societies and over time. Gender influences how people view themselves and each other, how they behave and interact and how power is distributed in society. Sex and gender are often incorrectly portrayed as binary (female/male or woman/man) and unchanging whereas these constructs actually exist along a spectrum and include additional sex categorizations and gender identities such as people who are intersex/have differences of sex development (DSD) or identify as non-binary. Moreover, the terms "sex" and "gender" can be ambiguous—thus it is important for authors to define the manner in which they are used. In addition to this definition guidance and the SAGER guidelines, the resources on this page offer further insight around sex and gender in research studies.

    Author contributions

    For transparency, authors are required to submit an author statement file outlining their individual contributions to the paper using the relevant CRediT roles: Conceptualization; Data curation; Formal analysis; Funding acquisition; Investigation; Methodology; Project administration; Resources; Software; Supervision; Validation; Visualization; Roles/Writing - original draft; Writing - review & editing. Authorship statements should be formatted with the names of authors first and CRediT role(s) following. More details and an example. Please click here to view the author statement file.

    Changes to authorship

    Authors are expected to consider carefully the list and order of authors before submitting their manuscript and provide the definitive list of authors at the time of the original submission. Any addition, deletion or rearrangement of author names in the authorship list should be made only before the manuscript has been accepted and only if approved by the journal Editor. To request such a change, the Editor must receive the following from the corresponding author: (a) the reason for the change in author list and (b) written confirmation (e-mail, letter) from all authors that they agree with the addition, removal or rearrangement. In the case of addition or removal of authors, this includes confirmation from the author being added or removed.
    Only in exceptional circumstances will the Editor consider the addition, deletion or rearrangement of authors after the manuscript has been accepted. While the Editor considers the request, publication of the manuscript will be suspended. If the manuscript has already been published in an online issue, any requests approved by the Editor will result in a corrigendum.

    Clinical trial results

    In line with the position of the International Committee of Medical Journal Editors, the journal will not consider results posted in the same clinical trials registry in which primary registration resides to be prior publication if the results posted are presented in the form of a brief structured (less than 500 words) abstract or table. However, divulging results in other circumstances (e.g., investors' meetings) is discouraged and may jeopardise consideration of the manuscript. Authors should fully disclose all posting in registries of results of the same or closely related work.

    Reporting clinical trials

    Randomized controlled trials should be presented according to the CONSORT guidelines. At manuscript submission, authors must provide the CONSORT checklist accompanied by a flow diagram that illustrates the progress of patients through the trial, including recruitment, enrollment, randomization, withdrawal and completion, and a detailed description of the randomization procedure. The CONSORT checklist and template flow diagram are available online.

    Registration of clinical trials

    Registration in a public trials registry is a condition for publication of clinical trials in this journal in accordance with International Committee of Medical Journal Editors recommendations. Trials must register at or before the onset of patient enrolment. The clinical trial registration number should be included at the end of the abstract of the article. A clinical trial is defined as any research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects of health outcomes. Health-related interventions include any intervention used to modify a biomedical or health-related outcome (for example drugs, surgical procedures, devices, behavioural treatments, dietary interventions, and process-of-care changes). Health outcomes include any biomedical or health-related measures obtained in patients or participants, including pharmacokinetic measures and adverse events. Purely observational studies (those in which the assignment of the medical intervention is not at the discretion of the investigator) will not require registration.

    Copyright

    Upon acceptance of an article, authors will be asked to complete a 'License Agreement' (see more information on this). Permitted third party reuse of open access articles is determined by the author's choice of user license.

    Author rights
    As an author you (or your employer or institution) have certain rights to reuse your work. More information.

    Elsevier supports responsible sharing

    Find out how you can share your research published in Elsevier journals.

    Role of the funding source

    You are requested to identify who provided financial support for the conduct of the research and/or preparation of the article and to briefly describe the role of the sponsor(s), if any, in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication. If the funding source(s) had no such involvement, it is recommended to state this.

    Open Access

    Please visit our Open Access page from the Journal Homepage for more information.

    If you cannot afford the fees to get your article published open access, then individual waiver requests are considered on a case-by-case basis and may be granted in cases of genuine need. Please click on https://service.elsevier.com/app/answers/detail/a_id/5973/supporthub/publishing/~/what-is-elseviers-waiver-policy-for-open-access-fees%3F/ for more information. If you are not eligible via Research4Life, please contact us at [email protected] for more details. Please note that all waiver requests must be submitted prior to the article's acceptance.

    Publication charges:Article publishing charges (APCs) are reasonably priced at $2,000 for ASBMB members or $2,500 for nonmembers, excluding taxes. Please be advised APCs for new submissions will increase starting January 1, 2023, to $2,300 for members and $2,800 for nonmembers, excluding taxes. These papers will be published under a CC-BY license. In order to qualify for the member discount, the corresponding author entered in Editorial Manager must be the ASBMB member.






    Available tools for authors

    Elsevier Researcher Academy

    Researcher Academy is a free e-learning platform designed to support early and mid-career researchers throughout their research journey. The "Learn" environment at Researcher Academy offers several interactive modules, webinars, downloadable guides and resources to guide you through the process of writing for research and going through peer review. Feel free to use these free resources to improve your submission and navigate the publication process with ease.

    Language (usage and editing services)

    Please write your text in good English (American or British usage is accepted, but not a mixture of these). Authors who feel their English language manuscript may require editing to eliminate possible grammatical or spelling errors and to conform to correct scientific English may wish to use the English Language Editing service available from Elsevier's Author Services.

    Submission

    Our online submission system guides you stepwise through the process of entering your article details and uploading your files. The system converts your article files to a single PDF file used in the peer-review process. Editable Word files are required to typeset your article for final publication. All correspondence, including notification of the Editor's decision and requests for revision, is sent by e-mail.

    Queries

    For questions about the editorial process (including the status of manuscripts under review) or for technical support on submissions, please visit our Support Center.

    Use of word processing software

    It is important that the file be saved in the native format of the word processor used. The text should be in single-column format. Keep the layout of the text as simple as possible. Most formatting codes will be removed and replaced on processing the article. In particular, do not use the word processor's options to justify text or to hyphenate words. However, do use bold face, italics, subscripts, superscripts etc. When preparing tables, if you are using a table grid, use only one grid for each individual table and not a grid for each row. If no grid is used, use tabs, not spaces, to align columns. The electronic text should be prepared in a way very similar to that of conventional manuscripts (see also the Guide to Publishing with Elsevier). Note that source files of figures, tables and text graphics will be required whether or not you embed your figures in the text. See also the section on Electronic artwork.
    To avoid unnecessary errors you are strongly advised to use the 'spell-check' and 'grammar-check' functions of your word processor.

    Article structure

    Formatting your manuscript file

    Our editorial system, Editorial Manager, automatically extracts the information from your submitted file to save you time during submission. Therefore, a PDF is not an acceptable source file for the manuscript. Only editable source files must be uploaded for the main manuscript file - including figure captions, and these will typically have the extension .docx, or .doc. We strongly recommend you use the formatting described here to enter authors names and section titles in your manuscript file. This will allow our editorial system to automatically extract manuscript information and prefill many of the required submission fields on the following pages, saving you a lot of time during the submission.

    Preparing the text and tables

    The following guidelines apply to regular research, methods, and patient-oriented and epidemiological research articles. Manuscripts must be written in English. Please note that, if accepted, JLR will automatically publish the accepted version of the manuscript online as a JLR Paper in Press (in PDF format), without copyediting or typesetting. Therefore, it is critical that the manuscript is prepared with great care before submitting online. It is particularly important that the title and authors are correct, since this information will become part of the paper's permanent record in PubMed.

    JLR does not set a specific word limit for submitted manuscripts, but encourages authors to be concise.



    Text and table formatting requirements

    • Prepared using Microsoft Word;
    • double-spaced;
    • without line numbering;
    • 11-point Times New Roman font;
    • 8.5-by-11-inch paper size (U.S. letter).


    Order of sections

    1. Title page
    2. Abstract and keywords
    3. Introduction
    4. Materials and Methods
    5. Results
    6. Discussion
    7. Data availability statement
    8. Acknowledgments
    9. References
    10. Footnotes to text (if any)
    11. Tables
    12. Figure legends (figures should be provided as individual source files and not be embedded in the Word document)


    Title page

    The title page should include the following information.
    • Title: Limited to two printed lines, about 120 characters including spaces.
    • Authors: Full names and affiliations (Department, Institution, City, State/Province (if applicable), Country)—indicate which author will accept correspondence and proofs.
    • Contact information for corresponding author: Please note that more than one corresponding author may be present on the final published manuscript, but for the purpose of the editorial system only one needs to be chosen during submission. The following details must be provided for that corresponding author: Full name; Full affiliation (Department, Institution, City, State/Province (if applicable), Country, Full postal address, Contact phone; E-mail address (institutional address must be provided as alternate e-mail in case a non-institutional e-mail is used).
    • Short title: Abbreviated title of maximum 60 characters including spaces.
    • Funding sources: List funding sources in this standard way to facilitate compliance to funder's requirements: Funding: This work was supported by the National Institutes of Health [grant numbers xxxx, yyyy]; the Bill & Melinda Gates Foundation, Seattle, WA [grant number zzzz]; and the United States Institutes of Peace [grant number aaaa]. It is not necessary to include detailed descriptions on the program or type of grants and awards. When funding is from a block grant or other resources available to a university, college, or other research institution, submit the name of the institute or organization that provided the funding. If no funding has been provided for the research, please include the following sentence: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
    • Abbreviations: Any abbreviations not found on the JLR abbreviation list.


    Characters

    Only characters that can be encoded in Unicode such as Chinese, Japanese, Korean, Cyrillic, and Arabic are acceptable. Non-Latin characters can only be used for author names, not author affiliations or titles.

    Abstract

    • 250 word limit.
    • States objectives and new findings.
    • Unstructured preferred. Ends with a short conclusion of two or three sentences.
    • Contains no references.


    Keywords

    • At least five keywords from this list (keywords are equivalent to editorial board members' expertise terms).
    • Up to five free-form keywords.
    • Maximum of ten keywords in total.
    • Should not appear in title or running title.
    • Listed on the abstract page.


    Data availability

    • Must indicate where the data described in the manuscript are located. If all data are contained within the manuscript, then the statement should indicate so. If data are to be shared upon request, then the individual along with their contact information (institution and email address) must be indicated.
    • For datasets that were deposited into a publicly accessible repository, the location and identifying information (i.e., accession numbers) must be provided.
    • Software code should be archived in a repository that can assign it a DOI and the DOI should be provided. If DOIs cannot be provided at submission, include placeholder language to indicate that DOIs will be made available after acceptance.
    • Any exceptions or limitations to the sharing of data, materials, and software must be described in this section.


    Acknowledgments

    • Can include any brief note(s) of thanks to people who helped with the study and any references to sources of material.
    • Should not contain funding sources for the research/study, disclosures, statements of equal contribution, or author contributions. These should be moved to their appropriate sections.


    References

    • Responsibility for the accuracy of the references lies solely with the author(s).
    • References should be cited in text using only numbers in parentheses (Vancouver citation style).
    • Citations should be numbered consecutively in order of appearance in the text.
    • Reference list should be double-spaced.
    • All authors, all titles, and inclusive pages are to be listed.
    • Abbreviations of journals should conform to those used in Index Medicus, United States National Library of Medicine.
    • Previously deposited/published datasets should be provided as a reference along with the article describing the dataset. The data citation should be formatted using the general format (see example 4): [dataset] Creator(s)/Author(s). (Publication Year) Title. Repository. Version (if applicable), Global Persistent Identifier.
    • Preprints may be cited in the reference list of the article (see example 5).
    • All references should be included in this section. If any references are cited in the Supplemental Data, they should be included in the References of the main text and cited in the Supplemental Data section at the end of the article. The numbering of the citations in the Supplemental Data should start after the last reference in the main text.


    Reference list formatting examples:
    1. Journal article: Klucken, J., Buchler, C., Orso, E., Kaminski, W. E., Porsch-Ozcurumez, M., Liebisch, G., et al. (2000) ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. Proc Natl Acad Sci U.S.A. 97, 817-822
    2. Book with authors: Maniatis, T., Fritsch, E. F., and Sambrook, J. (1982) Molecular Cloning: A Laboratory Manual, 3rd Ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
    3. Article or chapter in book with editors: Meltzer, P. S., Kallioniemi, A., and Trent, J. M. (2002) Chromosome alterations in human solid tumors. In The Genetic Basis of Human Cancer,Vol. 2. B. Vogelstein and K. W. Kinzler, editors. McGraw-Hill, New York. Chapter 5, 93-113
    4. Dataset: Hansson, O., Donsmark, M., Ling, C., Nevsten, P. Danfelter, M. Andersen, J. L., et al. (2008) Transcription profiling of mouse soleus muscle from hormone sensitive lipase-null animals. ArrayExpress. E-GEOD-1772.
    5. Preprint: Nikitina, T., Norouzi, D., Grigoryev, S. A., and Zhurkin, V. B. (2017) DNA topology in chromatin is defined by nucleosome spacing. bioRxiv 10.1101/104083


    Unpublished observations, websites, personal communications:
    • Should not appear in reference list.
    • Cited in parentheses in text, including names and initials of all authors.
    • Written approval by the person(s) cited in personal communications must accompany the manuscript.
    • Papers accepted for publication but that have not been published yet may appear in the reference list with the words "In press" in place of the volume number and page range and also include the DOI number. Submit a PDF file of "In press" articles with the manuscript.
    • References to abstracts are permitted only when the abstract is the sole source of the information.


    Tables

    • Each table should be uploaded as a separate file.
    • Include the title and footnotes in the manuscript file:
      • Titles should be descriptive.
      • Double-spaced and numbered with Arabic numbers.
      • Intelligible without reference to the text.
      • Footnotes indicated by superscripted, lowercase italic letters.
    • Tables should be cited in text in order.


    Abbreviations and text conventions

    • Abbreviations on the JLR abbreviation list may be used without definition in JLR.
    • All other abbreviations should be explained in an unnumbered footnote on the title page.
    • Abbreviated terms should also be defined on first occurrence in the abstract and text.
    • Single letter abbreviations are discouraged.


    For common abbreviations and other points of style, JLR follows these conventions:
    • Scientific Style and Format, The CSE Manual for Authors, Editors, and Publishers, 2014, 8th edition, prepared by the Council of Biology Editors, Inc., and published for the Council of Biology Editors by the Press Syndicate of the University of Cambridge, New York;
    • Lipid classification, nomenclature and structural representation: JLR recommends the use of the classification, nomenclature and structural representation of lipids used by the LIPID MAPS Initiative (see Fahy et al. J. Lipid Res. 2005 46: 839-862 and Fahy et al. J. Lipid Res. 2009 50: S9-S14). Lipid structures can be downloaded directly from the "Lipid Classification" section of the LIPID MAPS Web site (http://www.lipidmaps.org) or structures can be drawn de novo from the "Tools" section of the website, and then inserted into figures.
    • Chemical nomenclature: Chemical Abstracts; and
    • Enzyme terminology: Nomenclature Committee of the International Union of Biochemistry and Molecular Biology


    Requirements for data reporting

    Authors must follow ASBMB's policies for reporting and depositing information related to new sequences, 'omics datasets, and structural data described here to avoid delays in review or publication. In addition, authors must adhere to the following guidelines for lipidomics data and deposition of novel lipid structures.

    Lipidomics



    These guidelines have been developed by JLR, which are similar to those used to study plasma lipidomes, for reporting lipidomics data in these areas (Burla et al. (2018) J. Lipid Res. 59, 2001-2017).

    Specifically, lipid species must be identified to the capacity of individual lipidomics platforms. No ion features are allowed. Lipidomics data must be quantitative with internal standards (at least one internal standard per lipid class is required). Addition of internal standards should be normalized to a denominator (e.g., solution volume, protein or DNA content, tissue weight, cell number, etc.) in order to be validated by and/or compared to other methods, platforms, and laboratories. Internal standards should be added at the earliest time possible in sample preparation to minimize extraction/recovery issues. Mechanistic insights must be provided regarding the observed changes in lipid species.

    The use of the classification, nomenclature and structural representation of lipids used by the LIPID MAPS Initiative should be used whenever possible (see Fahy et al. (2005) J. Lipid Res. 46, 839?862 and Fahy et al. (2009) J. Lipid Res. 50, S9?S14). Lipid species annotation recommended previously (Liebisch et al. (2013) J. Lipid Res. 54, 1523-1530) should be used for consistency for lipidomics data sets.

    Depositing novel lipid structures in LIPID MAPS database

    JLR recommends that authors deposit all novel lipid molecules for registration in the LIPID MAPS structure database prior to publication.

    Structures can be registered at http://www.lipidmaps.org/new/reg/index.html. Structures will be validated for uniqueness and checked for correct nomenclature before being placed in the public database. Questions regarding the submission of structures should be directed to [email protected].

    Benefits of using LIPID MAPS:
    • maintaining and expanding a comprehensive lipid database covering a wide variety of organisms;
    • accurately classifying new lipid structures;
    • applying consistent nomenclature standards with regard to systematic names and abbreviations;
    • having consistent and unambiguous structural representation.


    Graphical abstract

    Although a graphical abstract is optional, its use is encouraged as it draws more attention to the online article. The graphical abstract should summarize the contents of the article in a concise, pictorial form designed to capture the attention of a wide readership. Graphical abstracts should be submitted as a separate file in the online submission system. Image size: Please provide an image with a minimum of 531 × 1328 pixels (h × w) or proportionally more. The image should be readable at a size of 5 × 13 cm using a regular screen resolution of 96 dpi. Preferred file types: TIFF, EPS, PDF or MS Office files. You can view Example Graphical Abstracts on our information site.

    Artwork

    For publication at JLR, authors must include at least one molecular weight marker in electrophoretic gels (though markers above and below the band(s) of interest are preferred). Authors must also include appropriate rulers or scale bars in any microscopy images and in any photographic images of tissues or animals. Detailed information about these and other best practices related to data analysis/presentation can be found on JBC's Authors resources page. Please review this information carefully to avoid publication delays stemming from the use of poor quality images or inappropriately spliced gels, etc. Authors should keep the number of illustrations to a minimum. Figures should be intelligible without reference to the text.

    Please provide individual source files (i.e., .tif, .tiff, .pdf, .ps, .eps, .jpg, .jpeg, .gif, .bmp, .psd, or .png) for any figures included with your submission (note that these are required at the revision stage). Figures should not be embedded within or at the end of your manuscript Word file. Please include the individual figure number in the "Description" field in Editorial Manager and in the file name for each figure. See this example of a properly formatted manuscript.

    Color figures

    All color figures must be in RGB format. ICC profiles should be embedded. Because color blindness affects 5-10% of the population it is recommended that you create figures that are accessible to all, including those with impaired color vision. Please follow these five guidelines: 1) use a color-blind safe palette; 2) use sufficiently high contrast; 3) in fluorescent red-green images, replace red with magenta; 4) simulate how your design would look to the color-blind eye using one of the many free tools or the "Proof setup" function in Adobe Photoshop; 5) consider if you really need to use color to represent your data or if monochromatic figures, or different shapes, positions and line types could be used instead.

    Figure format and resolution requirements for accepted manuscripts

    Figures supplied in EPS format should have all fonts converted to outlines/paths to avoid problems with character substitutions (in Adobe Illustrator, choose Edit "Select All then Type " Create Outlines).

    Figure Requirements

    Text and lines in figures

    • Use Helvetica typeface when possible.
    • Lines must be 0.25 pt thickness or greater.
    • Embed fonts in vector files, such as those created with Adobe Illustrator.


    Figure permissions and reuse

    All submissions should contain the appropriate permissions statements for reuse of content from previous publications. If you are not sure whether you need permissions for any figures, please click here for a simple guide.

    Figure captions

    Ensure that each illustration has a caption. Supply captions separately, not attached to the figure. A caption should comprise a brief title (not on the figure itself) and a description of the illustration. Keep text in the illustrations themselves to a minimum but explain all symbols and abbreviations used.

    Preprint references

    Where a preprint has subsequently become available as a peer-reviewed publication, the formal publication should be used as the reference. If there are preprints that are central to your work or that cover crucial developments in the topic, but are not yet formally published, these may be referenced. Preprints should be clearly marked as such, for example by including the word preprint, or the name of the preprint server, as part of the reference. The preprint DOI should also be provided.

    Preparing supplemental data

    Allowable supplemental data

    Manuscripts must NOT be dependent on supplemental data. The manuscript is a complete, stand-alone record of research. However, data that is impossible or impractical to include in the manuscript may be provided as an online supplement. Examples include videos, long lists of primers, 3-D structures/images, large sequence alignments and datasets obtained from microarray hybridization or mass spectrometry. Data that would be important and useful to specialists, such as chemical structures, spectra, and kinetic plots that are not critical to the manuscript, are also permitted. Please refer here for instructions on how to create 3-D files for submission as supplemental files.

    Supplemental data should NOT contain preliminary data that simply extends the scope of the study, unnecessary "control" data, or data that are thought to be not rigorous enough for the main text. Some novel methodology may be presented in detail in the supplemental data, but it should not be viewed as a "depository" for most methods; the main text should contain sufficient methodology for an experienced investigator to replicate the experiments.

    Links to author or third-party sites for such information are not allowed because they lack permanence, but links to "official" databases like GenBank are encouraged.

    Supplemental data review process

    Supplemental data will be reviewed as a part of the normal manuscript review process and will be judged by the same rigorous criteria as the main body of the paper. Only data that are deemed appropriate for the journal and substantially contribute to the manuscript will be accepted. Supplemental data submitted during review will require that the paper be reviewed again thus extending the review process. Supplemental data submitted after the paper has been accepted will not be published.

    Authors should carefully review the supplemental data for factual, grammatical, and typographical issues since this material will not be professionally copyedited but permanently posted "as is."

    If your article contains supplemental data please include a sentence stating "This article contains supplemental data." Any references cited in the Supplemental Data should be cited in this sentence.

    Supplemental data file formats

    Supplemental data, figures, and tables should NOT be included in the main manuscript PDF file. Compatible data files MUST BE combined into a single PDF (click here to see an example). Movies and large Excel files should be submitted in their native formats. Supplemental tables and figures (one per page) should each have a descriptive title and should be prepared double-spaced and numbered with Arabic numerals (e.g., supplemental Figure S1, supplemental Figure S2, supplemental Table S1, etc.), including callouts to the supplemental data in the manuscript. Figure and table legends should also be included on the same page with its corresponding figure or table.

    The following Supporting Information file formats are accepted: avi, doc, docx, gif, html, jpg, mov, mpg, pdb, pdf, ppt, pptx, txt, wmv, xls, xlsx, and zip.

    Cover letter

    A cover letter may accompany the manuscript and should be uploaded as a separate file. The cover letter must not be included in the body of the manuscript. The cover letter may include:
    • Statement regarding prior publication.
    • Statement disclosing any conflicts of interest.
    • If any listed authors have not seen and approved the manuscript as submitted, an explanation as to why (e.g., deceased author, author unreachable because out of country, etc.).
    • Indication of whether supplemental material is being submitted with the manuscript, and whether the supplemental material is for publication online or is intended for the reviewers only.


    Resubmissions

    When an author has been invited by an Editor to resubmit a revised manuscript, the resubmission must be accompanied by a cover letter that includes a detailed point-by-point listing as to how each of the reviewers' comments has been addressed and describes any other changes made to the manuscript.




    Availability of accepted article

    This journal makes articles available online as soon as possible after acceptance. This concerns the Journal Pre-proofs (both in HTML and PDF format), which have undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but are not yet the definitive versions of record. A Digital Object Identifier (DOI) is allocated, thereby making it fully citable and searchable by title, author name(s) and the full text. The article's PDF also carries a disclaimer stating that it is an unedited article. Subsequent production stages will simply replace this version.

    Online proof correction

    To ensure a fast publication process of the article, we kindly ask authors to provide us with their proof corrections within two days. Corresponding authors will receive an e-mail with a link to our online proofing system, allowing annotation and correction of proofs online. The environment is similar to MS Word: in addition to editing text, you can also comment on figures/tables and answer questions from the Copy Editor. Web-based proofing provides a faster and less error-prone process by allowing you to directly type your corrections, eliminating the potential introduction of errors.
    If preferred, you can still choose to annotate and upload your edits on the PDF version. All instructions for proofing will be given in the e-mail we send to authors, including alternative methods to the online version and PDF.
    We will do everything possible to get your article published quickly and accurately. Please use this proof only for checking the typesetting, editing, completeness and correctness of the text, tables and figures. Significant changes to the article as accepted for publication will only be considered at this stage with permission from the Editor. It is important to ensure that all corrections are sent back to us in one communication. Please check carefully before replying, as inclusion of any subsequent corrections cannot be guaranteed. Proofreading is solely your responsibility.

    Offprints

    The corresponding author will be notified and receive a link to the published version of the open access article on ScienceDirect. This link is in the form of an article DOI link which can be shared via email and social networks.




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