May 2016
Volume 57Issue 5p745-916
Open Access
COVER: Lp(a), through its apo(a) component, promotes coagulation and inhibits fibrinolysis
through several mechanisms. Apo(a)/Lp(a) promotes coagulation by inhibiting tissue
factor pathway inhibitor (TFPI) activity (A) and by promoting platelet activation
(B). Apo(a)/Lp(a) inhibits fibrinolysis by downregulating tPA-mediated plasminogen
(Plg) activation (C), downregulating plasmin-mediated conversion of Glu-plasminogen
to Lys-plasminogen (D), and promoting the formation of fibrin with thinner fibers
and a more dense structure that is resistant to lysis (E). Together, these effects
lead to a potential prothrombotic effect of Lp(a). (See Boffa and Koschinsky, p. 745.)...Show more
COVER: Lp(a), through its apo(a) component, promotes coagulation and inhibits fibrinolysis
through several mechanisms. Apo(a)/Lp(a) promotes coagulation by inhibiting tissue
factor pathway inhibitor (TFPI) activity (A) and by promoting platelet activation
(B). Apo(a)/Lp(a) inhibits fibrinolysis by downregulating tPA-mediated plasminogen
(Plg) activation (C), downregulating plasmin-mediated conversion of Glu-plasminogen
to Lys-plasminogen (D), and promoting the formation of fibrin with thinner fibers
and a more dense structure that is resistant to lysis (E). Together, these effects
lead to a potential prothrombotic effect of Lp(a). (See Boffa and Koschinsky, p. 745.)
