January 2014
Volume 55Issue 1p1-164
Open Access
COVER: Postulated roles of two cytochrome P450-containing enzymes, CYP27B1 and CYP24A1,
in establishing the optimal target cell concentration of the active form of vitamin
D3, 1,25-(OH)2D3 for regulation of gene expression in the non-calcemic functions of
vitamin D. Cytokines (IFNγ, IL4) are believed to regulate these extra-renal/target
cell enzymes. Normal cells balance synthesis and degradation to generate optimal levels
of 1,25-(OH)2D3. Cancer cells show reduced CYP27B1 and increased CYP24A1 expression
to lower the level of the anti-proliferative hormone and ensure cell division. (See Jones et al., p. 13.)...Show more
COVER: Postulated roles of two cytochrome P450-containing enzymes, CYP27B1 and CYP24A1,
in establishing the optimal target cell concentration of the active form of vitamin
D3, 1,25-(OH)2D3 for regulation of gene expression in the non-calcemic functions of
vitamin D. Cytokines (IFNγ, IL4) are believed to regulate these extra-renal/target
cell enzymes. Normal cells balance synthesis and degradation to generate optimal levels
of 1,25-(OH)2D3. Cancer cells show reduced CYP27B1 and increased CYP24A1 expression
to lower the level of the anti-proliferative hormone and ensure cell division. (See Jones et al., p. 13.)
