June 2019

Volume 60Issue 6p1067-1182
Open Access
COVER: S1P is formed intracellularly by the phosphorylation of sphingosine, and S1P must be secreted from cells in order to signal through a family of cell surface G protein-coupled receptors. One important transporter of S1P is spinster 2 (SPNS2). Recent studies have shown that SPNS2-mediated secretion of S1P has important roles in the trafficking of immune cells in both autoimmune diseases and cancer metastasis. (See Spiegel et al. in the JLR March issue, p. 484.)...
COVER: S1P is formed intracellularly by the phosphorylation of sphingosine, and S1P must be secreted from cells in order to signal through a family of cell surface G protein-coupled receptors. One important transporter of S1P is spinster 2 (SPNS2). Recent studies have shown that SPNS2-mediated secretion of S1P has important roles in the trafficking of immune cells in both autoimmune diseases and cancer metastasis. (See Spiegel et al. in the JLR March issue, p. 484.)

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