May 2019
Volume 60Issue 5p911-1066
Open Access
COVER: Ceramide has been proposed to regulate diverse cellular processes by influencing
membrane properties and by directly binding to effector proteins. Dysregulation of
ceramide metabolism results in altered cellular responses and has been implicated
in many diseases. Advances over the past decade have improved our understanding of
ceramide as a bioactive lipid, with promise for development of therapeutic strategies
to treat ceramide-regulated diseases. (See Stith et al., p. 913.)...Show more
COVER: Ceramide has been proposed to regulate diverse cellular processes by influencing
membrane properties and by directly binding to effector proteins. Dysregulation of
ceramide metabolism results in altered cellular responses and has been implicated
in many diseases. Advances over the past decade have improved our understanding of
ceramide as a bioactive lipid, with promise for development of therapeutic strategies
to treat ceramide-regulated diseases. (See Stith et al., p. 913.)
