October 2019
Volume 60Issue 10p1643-1801
Open Access
COVER: Potential organization of a protein assembly that links enzymes of de novo lipogenesis
and complex lipid synthesis. De novo lipogenesis via ATP citrate lyase (ATP CL), acetyl-coA
carboxylase (ACC), and fatty acid synthase (FAS) synthesizes fatty acids that are
activated by acyl-CoA synthetase (ACSL). The resulting acyl-CoAs are esterified by
glycerol-3-P acyltransferase (GPAT1), thereby providing the substrate for complex
lipid synthesis. Close enzyme interactions would facilitate this metabolic pathway.
(See Coleman in the JLR March issue , p. 490.)...Show more
COVER: Potential organization of a protein assembly that links enzymes of de novo lipogenesis
and complex lipid synthesis. De novo lipogenesis via ATP citrate lyase (ATP CL), acetyl-coA
carboxylase (ACC), and fatty acid synthase (FAS) synthesizes fatty acids that are
activated by acyl-CoA synthetase (ACSL). The resulting acyl-CoAs are esterified by
glycerol-3-P acyltransferase (GPAT1), thereby providing the substrate for complex
lipid synthesis. Close enzyme interactions would facilitate this metabolic pathway.
(See Coleman in the JLR March issue , p. 490.)
