October 2019

Volume 60Issue 10p1643-1801
Open Access
COVER: Potential organization of a protein assembly that links enzymes of de novo lipogenesis and complex lipid synthesis. De novo lipogenesis via ATP citrate lyase (ATP CL), acetyl-coA carboxylase (ACC), and fatty acid synthase (FAS) synthesizes fatty acids that are activated by acyl-CoA synthetase (ACSL). The resulting acyl-CoAs are esterified by glycerol-3-P acyltransferase (GPAT1), thereby providing the substrate for complex lipid synthesis. Close enzyme interactions would facilitate this metabolic pathway. (See Coleman in the JLR March issue , p. 490.)...
COVER: Potential organization of a protein assembly that links enzymes of de novo lipogenesis and complex lipid synthesis. De novo lipogenesis via ATP citrate lyase (ATP CL), acetyl-coA carboxylase (ACC), and fatty acid synthase (FAS) synthesizes fatty acids that are activated by acyl-CoA synthetase (ACSL). The resulting acyl-CoAs are esterified by glycerol-3-P acyltransferase (GPAT1), thereby providing the substrate for complex lipid synthesis. Close enzyme interactions would facilitate this metabolic pathway. (See Coleman in the JLR March issue , p. 490.)

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