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2018

Volume 59Issue 6p1-1080

Open Access

COVER: A cellular map of sphingolipid metabolism in the context of organelles that play a major role in sphingolipid processing is represented. Exogenously supplied odd chain d17dhSph is taken up from the media and incorporated into de novo sphingolipid metabolism within minutes. Utilizing mass spectrometry to follow the carbon deficient metabolic products establishes rates of label incorporation during the distinct temporal phases shown, which match the sequential transition from ER- to Golgi-based metabolism. The results can be utilized to assess relative activity for each of these enzymatic components in the sphingolipid network.(See Snider et al. p. 1046.)...Show more

COVER: A cellular map of sphingolipid metabolism in the context of organelles that play a major role in sphingolipid processing is represented. Exogenously supplied odd chain d17dhSph is taken up from the media and incorporated into de novo sphingolipid metabolism within minutes. Utilizing mass spectrometry to follow the carbon deficient metabolic products establishes rates of label incorporation during the distinct temporal phases shown, which match the sequential transition from ER- to Golgi-based metabolism. The results can be utilized to assess relative activity for each of these enzymatic components in the sphingolipid network.(See Snider et al. p. 1046.)

2018

Editorial Board

Tribute

In Memoriam: Angelo Scanu (1924-2018)¹

Thematic Review Series

Historical perspective: phosphatidylserine and phosphatidylethanolamine from the 1800s to the present

Research Articles

Chymase released from hypoxia-activated cardiac mast cells cleaves human apoA-I at Tyr¹⁹² and compromises its cardioprotective activity

Regulation of kynurenine metabolism by a ketogenic diet

Regulation of mitochondrial trifunctional protein modulates nonalcoholic fatty liver disease in mice

Adipocyte-specific DKO of Lkb1 and mTOR protects mice against HFD-induced obesity, but results in insulin resistance

FXR activation by obeticholic acid or nonsteroidal agonists induces a human-like lipoprotein cholesterol change in mice with humanized chimeric liver

Toxoplasma gondii acetyl-CoA synthetase is involved in fatty acid elongation (of long fatty acid chains) during tachyzoite life stages

The desA and desB genes from Clostridium scindens ATCC 35704 encode steroid-17,20-desmolase[S]

Patient-Oriented and Epidemiological Research

EPT1 (selenoprotein I) is critical for the neural development and maintenance of plasmalogen in humans[S]

Obstructive sleep apnea and effects of continuous positive airway pressure on triglyceride-rich lipoprotein metabolism^[S]

Abnormal liver phosphatidylcholine synthesis revealed in patients with acute respiratory distress syndrome

Methods

Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry[S]

Identification of unusual oxysterols and bile acids with 7-oxo or 3β,5α,6β-trihydroxy functions in human plasma by charge-tagging mass spectrometry with multistage fragmentation[S]

Multimodal imaging approach to monitor browning of adipose tissue in vivo[S]

ERRATUM

Author Index