October 2017
Volume 58Issue 10p1935-2082
Open Access
COVER: The underlying mechanisms by which the activation of nuclear receptors (NRs) exerts
beneficial effects in Alzheimer's disease can be grouped in 4 different classes: Aβ generation and neuronal function in neurons, Aβ clearance and anti-inflammatory mechanisms in glial cells. The overall effect of a particular NR agonist likely arises from
the modulation of these several different pathways, rather than only one particular
mechanism. (See Moutinho and Landreth, p. 1937.)...Show more
COVER: The underlying mechanisms by which the activation of nuclear receptors (NRs) exerts
beneficial effects in Alzheimer's disease can be grouped in 4 different classes: Aβ generation and neuronal function in neurons, Aβ clearance and anti-inflammatory mechanisms in glial cells. The overall effect of a particular NR agonist likely arises from
the modulation of these several different pathways, rather than only one particular
mechanism. (See Moutinho and Landreth, p. 1937.)
