August 2017

Volume 58Issue 8p1491-1730
Open Access
COVER: A Western diet induced interferon-β (IFN-β), cholesterol 25-hydroxylase (CH25H), and 25-hydroxycholesterol (25-OHC) in small intestine of mice. 25-OHC induces immune cells to produce inflammatory cytokines. Adding a concentrate of transgenic tomatoes expressing 6F peptide (Tg6F) to a Western diet partially ameliorated these changes, as did ezetimibe. Using a novel method to combine Tg6F with ezetimibe essentially prevented induction of IFN-β, CH25H, and 25-OHC. (See Mukherjee et al. p. 1636.)...
COVER: A Western diet induced interferon-β (IFN-β), cholesterol 25-hydroxylase (CH25H), and 25-hydroxycholesterol (25-OHC) in small intestine of mice. 25-OHC induces immune cells to produce inflammatory cytokines. Adding a concentrate of transgenic tomatoes expressing 6F peptide (Tg6F) to a Western diet partially ameliorated these changes, as did ezetimibe. Using a novel method to combine Tg6F with ezetimibe essentially prevented induction of IFN-β, CH25H, and 25-OHC. (See Mukherjee et al. p. 1636.)

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