November 2017
Volume 58Issue 11p2083-2238
Open Access
COVER: In diet-induced obesity, the IL-6 family cytokines are produced from adipocytes and
infiltrated immune cells in adipose tissue. IL-6 family cytokines upregulate ATX expression
in adipocytes through the gp130-JAK-STAT3 signaling pathway. The increased production
of adipocyte-derived ATX not only affects the adipose tissue inflammation and the
biological function of adipocytes but also results in elevation of plasma ATX and
LPA levels to contribute to insulin resistance. The obesity-associated insulin resistance
and glucose intolerance are ameliorated by inhibition of gp130 signaling. (See Sun et al., p. 2102.)...Show more
COVER: In diet-induced obesity, the IL-6 family cytokines are produced from adipocytes and
infiltrated immune cells in adipose tissue. IL-6 family cytokines upregulate ATX expression
in adipocytes through the gp130-JAK-STAT3 signaling pathway. The increased production
of adipocyte-derived ATX not only affects the adipose tissue inflammation and the
biological function of adipocytes but also results in elevation of plasma ATX and
LPA levels to contribute to insulin resistance. The obesity-associated insulin resistance
and glucose intolerance are ameliorated by inhibition of gp130 signaling. (See Sun et al., p. 2102.)
