May 2017
Volume 58Issue 5p823-1030
Open Access
COVER: ApoE metabolism and pathways by which apoE and Aβ interact in the brain. Solid black
arrows indicate normal secretion and lipidation of apoE by astrocytes. Solid blue
arrows indicate the aggregation cascade and potential clearance routes for Aβ through
the blood-brain barrier. Solid red arrows indicate pathways or processes that apoE
had been shown to influence in relation to Alzheimer's disease. Dashed blue arrow
indicates a small pool of Aβ-apoE complexes. Dashed red arrow indicates apoE's proposed
effect on Aβ production. (See Huynh et al., p. 824.)...Show more
COVER: ApoE metabolism and pathways by which apoE and Aβ interact in the brain. Solid black
arrows indicate normal secretion and lipidation of apoE by astrocytes. Solid blue
arrows indicate the aggregation cascade and potential clearance routes for Aβ through
the blood-brain barrier. Solid red arrows indicate pathways or processes that apoE
had been shown to influence in relation to Alzheimer's disease. Dashed blue arrow
indicates a small pool of Aβ-apoE complexes. Dashed red arrow indicates apoE's proposed
effect on Aβ production. (See Huynh et al., p. 824.)
