December 2018
Volume 59Issue 12p2255-2466
Open Access
COVER: LXR ligands, including 25HC, induce CH25H and IFN-γ expression. In turn, both enhance
25HC and IFN-γ production, indicating a positive antiviral loop among CH25H, 25HC,
and IFN-γ. Meanwhile, SULT2B1b converts 25HC into 25HC3S, which also inhibits viral
growth but keeps 25HC production under control. LXR plays a central role in 25HC actions
and homeostasis. (See Liu et al., p.2287.)...Show more
COVER: LXR ligands, including 25HC, induce CH25H and IFN-γ expression. In turn, both enhance
25HC and IFN-γ production, indicating a positive antiviral loop among CH25H, 25HC,
and IFN-γ. Meanwhile, SULT2B1b converts 25HC into 25HC3S, which also inhibits viral
growth but keeps 25HC production under control. LXR plays a central role in 25HC actions
and homeostasis. (See Liu et al., p.2287.)
