October 2018
Volume 59Issue 10p1793-2036
Open Access
COVER: Retinas afflicted with age-related macular degeneration (AMD) contain lipid-rich
lesions called drusen and subretinal drusenoid deposits (SDDs) between the retinal
pigment epithelium (RPE) and fenestrated choriocapillaris and between the RPE and
outer limiting membrane (OLM), respectively. Drusen and SDDs may interfere with water
and metabolite exchange between the tissues and cause neovascularization or death
of the RPE. The RPE may be a source of lipid in the lesions. The upper panel shows
the proposed pathways of lipid movement in and out of the RPE in HDL (blue arrows)
and apo B-lipoprotein (gray arrows) particles via ABCA1, LDL receptor (LDLR), and
secretion. The lower panel shows how accumulation of drusen-like deposits is studied
using highly polarized primary human fetal RPE monolayers grown on a porous support.
(See Lyssenko et al., p.1927.)...Show more
COVER: Retinas afflicted with age-related macular degeneration (AMD) contain lipid-rich
lesions called drusen and subretinal drusenoid deposits (SDDs) between the retinal
pigment epithelium (RPE) and fenestrated choriocapillaris and between the RPE and
outer limiting membrane (OLM), respectively. Drusen and SDDs may interfere with water
and metabolite exchange between the tissues and cause neovascularization or death
of the RPE. The RPE may be a source of lipid in the lesions. The upper panel shows
the proposed pathways of lipid movement in and out of the RPE in HDL (blue arrows)
and apo B-lipoprotein (gray arrows) particles via ABCA1, LDL receptor (LDLR), and
secretion. The lower panel shows how accumulation of drusen-like deposits is studied
using highly polarized primary human fetal RPE monolayers grown on a porous support.
(See Lyssenko et al., p.1927.)
