November 2014

Volume 55Issue 11p2198-2445
Open Access
COVER: Thyroid hormone (TH) exerts several important effects on lipid and lipoprotein metabolism in humans. Hepatic actions of TH are responsible for most of the positive effects including lowering of PCSK9 and LDL-cholesterol levels as well as reduction of apoB and Lp(a). Bile acid synthesis is stimulated in hyperthyroidism, but this does not appear critical for lowering LDL-cholesterol. Intestinal actions of TH for its pronounced effects on bile acid synthesis and cholesterol absorption seem more important than previously recognized. Selective activation of TH receptors in the liver lowers plasma triglycerides whereas a concomitant stimulation of peripheral lipolysis during hyperthyroidism counteracts this action. (See Bonde et al. p. 2408.)...
COVER: Thyroid hormone (TH) exerts several important effects on lipid and lipoprotein metabolism in humans. Hepatic actions of TH are responsible for most of the positive effects including lowering of PCSK9 and LDL-cholesterol levels as well as reduction of apoB and Lp(a). Bile acid synthesis is stimulated in hyperthyroidism, but this does not appear critical for lowering LDL-cholesterol. Intestinal actions of TH for its pronounced effects on bile acid synthesis and cholesterol absorption seem more important than previously recognized. Selective activation of TH receptors in the liver lowers plasma triglycerides whereas a concomitant stimulation of peripheral lipolysis during hyperthyroidism counteracts this action. (See Bonde et al. p. 2408.)

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