September 2013

Volume 54Issue 9p2293-2574
Open Access
COVER: The cell in this figure is the gut bacterium Clostridium scindens. This figure shows how cortisol metabolized to the androgen 11betahydroxyandrostenedione by steroid-17,20-desmolase enzyme (central line). Feeding into this are genes that are upregulated by cortisol, including a number that are involved in synthesizing thiamine pyrophosphate, a cofactor for transketolase enzymes, which the steroid-17,20-desmolase is hypothesized to have evolved from. The two carbons removed during removal of the steroid side-chain are hypothesized to feed into the pentose-phosphate pathway, genes of which are upregulated by cortisol-induction. (See Ridlon et al., p. 2437.)...
COVER: The cell in this figure is the gut bacterium Clostridium scindens. This figure shows how cortisol metabolized to the androgen 11betahydroxyandrostenedione by steroid-17,20-desmolase enzyme (central line). Feeding into this are genes that are upregulated by cortisol, including a number that are involved in synthesizing thiamine pyrophosphate, a cofactor for transketolase enzymes, which the steroid-17,20-desmolase is hypothesized to have evolved from. The two carbons removed during removal of the steroid side-chain are hypothesized to feed into the pentose-phosphate pathway, genes of which are upregulated by cortisol-induction. (See Ridlon et al., p. 2437.)

Thematic Review Series: Fat-Soluble Vitamins: Vitamin E

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