March 2016
Volume 57Issue 3p333-516
Open Access
COVER: The cover figure displays lipoprotein (a) and its affect on coronary atherosclerosis
and aortic stenosis. On the top left is a depiction of the structure of Lp(a), which
is composed of an LDL-like particle and apolipoprotein (a). This particular apo(a)
isoform is composed of four KIV2 repeats. Lp(a) also contains oxidized phospholipids (OxPL) present n the lipid phase
of LDL and covalently bound to apo(a) near KIV10-KV. The effect of Lp(a) is then demonstrated on the heart at the aortic valve and
in the left anterior descending coronary artery. The insets show that when plasma
Lp(a) levels are elevated, it mediates the development of fibrosis and calcification
of the aortic valve leaflets leading to aortic stenosis as well as coronary atherosclerosis.
Concept by Sotirios Tsimikas, adaptation by Tracy Reigle....Show more
COVER: The cover figure displays lipoprotein (a) and its affect on coronary atherosclerosis
and aortic stenosis. On the top left is a depiction of the structure of Lp(a), which
is composed of an LDL-like particle and apolipoprotein (a). This particular apo(a)
isoform is composed of four KIV2 repeats. Lp(a) also contains oxidized phospholipids (OxPL) present n the lipid phase
of LDL and covalently bound to apo(a) near KIV10-KV. The effect of Lp(a) is then demonstrated on the heart at the aortic valve and
in the left anterior descending coronary artery. The insets show that when plasma
Lp(a) levels are elevated, it mediates the development of fibrosis and calcification
of the aortic valve leaflets leading to aortic stenosis as well as coronary atherosclerosis.
Concept by Sotirios Tsimikas, adaptation by Tracy Reigle.
