November 2012
Volume 53Issue 11p2253-2485
Open Access
COVER: Paraoxonase 1 (PON1) is an HDL-associated antioxidant enzyme with broad substrate
specificity and strong associations to numerous human diseases. This figure illustrates
the percentage of PON1 enzyme activity that is attributable to dietary (bolded) and
genetic factors identified in our study utilizing regression methods, in decreasing
order of magnitude. The associations of dietary cholesterol, iron in non-anemic patients,
and folic acid are, to the best of the authors' knowledge, novel, while we also confirm
past reports of vitamin C and alcohol use on PON1 activity. (See Kim et al. p. 2450.)...Show more
COVER: Paraoxonase 1 (PON1) is an HDL-associated antioxidant enzyme with broad substrate
specificity and strong associations to numerous human diseases. This figure illustrates
the percentage of PON1 enzyme activity that is attributable to dietary (bolded) and
genetic factors identified in our study utilizing regression methods, in decreasing
order of magnitude. The associations of dietary cholesterol, iron in non-anemic patients,
and folic acid are, to the best of the authors' knowledge, novel, while we also confirm
past reports of vitamin C and alcohol use on PON1 activity. (See Kim et al. p. 2450.)
