July 2022

Volume 63Issue 7
Open Access
Electron microscopy reveal distinct defects in lipoprotein particle assembly in livers of mice with impaired VLDL secretion. Nascent lipoprotein particles are visible in ER/Golgi apparatus in wild type mice (top, arrowheads) and mice with liver specific deletion of Tm6sf2 (middle), but not in Golgi of mice with liver specific deletion of Mttp (lower). Scale bar 100nm for all panels....
Electron microscopy reveal distinct defects in lipoprotein particle assembly in livers of mice with impaired VLDL secretion. Nascent lipoprotein particles are visible in ER/Golgi apparatus in wild type mice (top, arrowheads) and mice with liver specific deletion of Tm6sf2 (middle), but not in Golgi of mice with liver specific deletion of Mttp (lower). Scale bar 100nm for all panels.

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