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February 2023

Volume 64Issue 2

Open Access

On The Cover: The extracellular signaling lipid, sphingosine-1-phosphate (S1P), is taken-up by cells and reutilized through a dephosphorylation-phosphorylation-dephosphorylation cycle. Plasma membrane PLPP3 (phospholipid phosphatase 3) dephosphorylates extracellular S1P to sphingosine, which enters cells and is rephosphorylated. The regenerated S1P is dephosphorylated a second time by SGPP1 (S1P phosphatase 1) at the endoplasmic reticulum to route sphingosine into complex sphingolipid synthesis. See article number 100225 by Kono et al....Show more

On The Cover: The extracellular signaling lipid, sphingosine-1-phosphate (S1P), is taken-up by cells and reutilized through a dephosphorylation-phosphorylation-dephosphorylation cycle. Plasma membrane PLPP3 (phospholipid phosphatase 3) dephosphorylates extracellular S1P to sphingosine, which enters cells and is rephosphorylated. The regenerated S1P is dephosphorylated a second time by SGPP1 (S1P phosphatase 1) at the endoplasmic reticulum to route sphingosine into complex sphingolipid synthesis. See article number 100225 by Kono et al.

February 2023

Cover

Images in Lipid Research

Stromal cell-derived NGF controls sympathetic innervation in subcutaneous fat

Research Article

Liver-specific FGFR4 knockdown in mice on an HFD increases bile acid synthesis and improves hepatic steatosis

Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages

Dysregulated ceramide metabolism in mouse progressive dermatitis resulting from constitutive activation of Jak1

High-density lipoproteins mediate small RNA intercellular communication between dendritic cells and macrophages

Genetic deletion or pharmacologic inhibition of the Nlrp3 inflammasome did not ameliorate experimental NASH

Human apoA-I[Lys107del] mutation affects lipid surface behavior of apoA-I and its ability to form large nascent HDL

Research Article Collection: Cholesterol Metabolism

2-Hydroxypropyl-β-cyclodextrin mitigates pathological changes in a mouse model of retinal cholesterol dyshomeostasis

Research Article Collection: Lipoprotein Biology

Serum opacity factor rescues fertility among female Scarb1^−/− mice by reducing HDL-free cholesterol bioavailability

Methods

A simple, highly sensitive, and facile method to quantify ceramide at the plasma membrane

Corrigendum

Correction: RGMa promotes dedifferentiation of vascular smooth muscle cells into a macrophage-like phenotype in vivo and in vitro