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May 2023

Volume 64Issue 5

Open Access

The widely used traditional RNA-seq protocols have intrinsic limitations that prevent the discovery of highly modified small non-coding RNAs. A newly developed PANDORA-seq overcomes RNA modification-elicited sequence interferences and unveils a tsRNA/rsRNA-enriched small non-coding RNA landscape in murine atherosclerotic intima. PANDORA-seq also detects many differentially expressed intimal tsRNAs/rsRNAs associated with atherosclerosis development. The figure was created using BioRender.com....Show more

The widely used traditional RNA-seq protocols have intrinsic limitations that prevent the discovery of highly modified small non-coding RNAs. A newly developed PANDORA-seq overcomes RNA modification-elicited sequence interferences and unveils a tsRNA/rsRNA-enriched small non-coding RNA landscape in murine atherosclerotic intima. PANDORA-seq also detects many differentially expressed intimal tsRNAs/rsRNAs associated with atherosclerosis development. The figure was created using BioRender.com.

May 2023

Cover

Research Article

Effect of omega-3 ethyl esters on the triglyceride-rich lipoprotein response to endotoxin challenge in healthy young men

Vascular lipid droplets formed in response to TNF, hypoxia, or OA: biochemical composition and prostacyclin generation

Ablation of pigment epithelium-derived factor receptor (PEDF-R/Pnpla2) causes photoreceptor degeneration

The intriguing molecular dynamics of Cer[EOS] in rigid skin barrier lipid layers requires improvement of the model

Insulin dysregulation drives mitochondrial cholesterol metabolite accumulation: initiating hepatic toxicity in nonalcoholic fatty liver disease

Cellular cholesterol loss by DHCR24 knockdown leads to Aβ production by changing APP intracellular localization

Serum amyloid A augments the atherogenic effects of cholesteryl ester transfer protein

ASTER-B regulates mitochondrial carotenoid transport and homeostasis

TLR4 in POMC neurons regulates thermogenesis in a sex-dependent manner

Role of enterocyte Enpp2 and autotaxin in regulating lipopolysaccharide levels, systemic inflammation, and atherosclerosis

Research Article Collection: Cholesterol Metabolism

Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6

Research Article Collection: Genetics and Lipids

The origin of long-chain fatty acids required for de novo ether lipid/plasmalogen synthesis

Methods

Novel ¹³C enrichment technique reveals early turnover of DHA in peripheral tissues

Relationship between hepatic and mitochondrial ceramides: a novel in vivo method to track ceramide synthesis