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JLR Patient-Oriented and Epidemiological Research
1 Results
- Patient-Oriented and Epidemiological ResearchOpen Access
Discovery and fine-mapping of loci associated with MUFAs through trans-ethnic meta-analysis in Chinese and European populations
Journal of Lipid ResearchVol. 58Issue 5p974–981Published online: March 15, 2017- Yao Hu
- Toshiko Tanaka
- Jingwen Zhu
- Weihua Guan
- Jason H.Y. Wu
- Bruce M. Psaty
- and others
Cited in Scopus: 11MUFAs are unsaturated FAs with one double bond and are derived from endogenous synthesis and dietary intake. Accumulating evidence has suggested that plasma and erythrocyte MUFA levels are associated with cardiometabolic disorders, including CVD, T2D, and metabolic syndrome (MS). Previous genome-wide association studies (GWASs) have identified seven loci for plasma and erythrocyte palmitoleic and oleic acid levels in populations of European origin. To identify additional MUFA-associated loci and the potential functional variant at each locus, we performed ethnic-specific GWAS meta-analyses and trans-ethnic meta-analyses in more than 15,000 participants of Chinese and European ancestry.
