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Author
- Bernstein, Paul S1
- Bunn, Janice Y1
- Choi, Hyungwon1
- Crain, Karen I1
- Ebenstein, David B1
- Fang, Jinling1
- Fukagawa, Naomi K1
- Gorusupudi, Aruna1
- Hageman, Gregory S1
- Kien, CLawrence1
- Koh, Hiromi WL1
- Koh, Woon-Puay1
- Koves, Timothy R1
- Liu, Aihua1
- Matthews, Dwight E1
- Muoio, Deborah M1
- Newman, John W1
- Ong, Choon Nam1
- Poynter, Matthew E1
- Stevens, Robert D1
- Su, Jin1
- Sun, Ye1
- Tarleton, Emily K1
- van Dam, Rob M1
- Yuan, Jian-Min1
Keyword
- diet and dietary lipids3
- age-related macular degeneration1
- cytokines1
- dehydrogenases1
- eicosanoids1
- elongation of very long-chain fatty acids elongase 41
- epidemiology1
- eye1
- fatty acid1
- fatty acid/metabolism1
- fatty acid/oxidation1
- heart1
- incomplete β-oxidation of fatty acids1
- inflammation1
- innate immunity1
- lipidomics1
- lipids1
- lipids/oxidation1
- macrophages/monocytes1
- oleic acid1
- omega-3 fatty acids1
- oxidized lipids1
- palmitic acid1
JLR Patient-Oriented and Epidemiological Research
3 Results
- Patient-Oriented and Epidemiological ResearchOpen Access
Plasma fatty acids, oxylipins, and risk of myocardial infarction: the Singapore Chinese Health Study
Journal of Lipid ResearchVol. 57Issue 7p1300–1307Published online: May 24, 2016- Ye Sun
- Hiromi W.L. Koh
- Hyungwon Choi
- Woon-Puay Koh
- Jian-Min Yuan
- John W. Newman
- and others
Cited in Scopus: 33We aimed to examine the prospective association between plasma FAs, oxylipins, and risk of acute myocardial infarction (AMI) in a Singapore Chinese population. A nested case-control study with 744 incident AMI cases and 744 matched controls aged 47–83 years was conducted within the Singapore Chinese Health Study. Nineteen plasma FAs and 12 oxylipins were quantified using MS. These were grouped into 12 FA clusters and 5 oxylipin clusters using hierarchical clustering, and their associations with AMI risk were assessed. - Patient-Oriented and Epidemiological ResearchOpen Access
Associations of human retinal very long-chain polyunsaturated fatty acids with dietary lipid biomarkers
Journal of Lipid ResearchVol. 57Issue 3p499–508Published online: January 13, 2016- Aruna Gorusupudi
- Aihua Liu
- Gregory S. Hageman
- Paul S. Bernstein
Cited in Scopus: 42The human retina is well-known to have unique lipid profiles enriched in long-chain polyunsaturated fatty acids (LC-PUFAs) and very long-chain polyunsaturated fatty acids (VLC-PUFAs) that appear to promote normal retinal structure and function, but the influence of diet on retinal lipid profiles in health and disease remains controversial. In this study, we examined two independent cohorts of donor eyes and related their retinal lipid profiles with systemic biomarkers of lipid intake. We found that serum and red blood cell lipids, and to a lesser extent orbital fat, are indeed excellent biomarkers of retinal lipid content and n-3/n-6 ratios in both the LC-PUFA and VLC-PUFA series. - Patient-Oriented and Epidemiological ResearchOpen Access
Increased palmitate intake: higher acylcarnitine concentrations without impaired progression of β-oxidation
Journal of Lipid ResearchVol. 56Issue 9p1795–1807Published online: July 8, 2015- C.Lawrence Kien
- Dwight E. Matthews
- Matthew E. Poynter
- Janice Y. Bunn
- Naomi K. Fukagawa
- Karen I. Crain
- and others
Cited in Scopus: 5Palmitic acid (PA) is associated with higher blood concentrations of medium-chain acylcarnitines (MCACs), and we hypothesized that PA may inhibit progression of FA β-oxidation. Using a cross-over design, 17 adults were fed high PA (HPA) and low PA/high oleic acid (HOA) diets, each for 3 weeks. The [1-13C]PA and [13-13C]PA tracers were administered with food in random order with each diet, and we assessed PA oxidation (PA OX) and serum AC concentration to determine whether a higher PA intake promoted incomplete PA OX.